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HomeProduct name listCefmenoxime hydrochloride

Cefmenoxime hydrochloride

  • CAS NO.:75738-58-8
  • Empirical Formula: C16H18ClN9O5S3
  • Molecular Weight: 548.01
  • MDL number: MFCD01750403
  • EINECS: 278-299-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 13:32:20
Cefmenoxime hydrochloride  Structural

What is Cefmenoxime hydrochloride ?

Description

Cef menoxime hydrochloride is a third generation cephalosporin antibiotic. Structurally, it possesses the (1-methyl-lH-tetrazol-5-yl)thiomethyl moiety in the 3-position; like several other compounds containing this structural element (moxalactam, cefoperazone, cefamandol), bleeding linked to vitamin K interaction has been reported. Cefmenoxime has activity similar to cefotiuime, ceftizoxime and moxalactam against E.coli, C. diversus, Klebsiella, P. Mirabilis, Salmonella, Shigella, Neiseria spp., S. pyogenes, S. Pneumoniae, and g. influenzae. It is relatively ineffective against Pseudomonas and Bacteroidea.

Originator

Takeda (Japan)

The Uses of Cefmenoxime hydrochloride

A third generation cephalosporin antibiotic with strong antimicrobial activities against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella subgenus Branhamella catarrhalis that were 3 major aerobic bacteria from sinusitis.

The Uses of Cefmenoxime hydrochloride

antibacterial

What are the applications of Application

Cefmenoxime hydrochloride is an antibacterial

Definition

ChEBI: The hemihydrochloride salt of cefmenoxime.

brand name

Cefmax (TAP);TACEF;BESTCALL.

General Description

Cefmenoxime was synthesized by Takeda Pharmaceutical Co. in 1978. It contains aminothiazole and methoxyimino groups in the 7-acyl position and a methyltetrazole group at the 3 position of the cephem nucleus. Cefmenoxime has a wide activity spectrum against gram-positive and gram-negative bacteria, including anaerobes, except Staphylococcus aureus. Cefmenoxime is a member of the so-called third-generation cephalosporins, a recently introduced class of clinically important antibiotics.

Properties of Cefmenoxime hydrochloride

Melting point: >175°C (dec.)
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
solubility  DMSO (Slightly, Heated), Methanol (Slightly)
form  Solid
color  Off-White to Pale Yellow

Safety information for Cefmenoxime hydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Cefmenoxime hydrochloride

InChIKey HZYJYGJIOCXOTH-AJVJENPNNA-N
SMILES C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC)C(=O)N12)CSC1=NN=NN1C)(=O)O.Cl |&1:5,7,r|

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