Cefmenoxime hydrochloride
- CAS NO.:75738-58-8
- Empirical Formula: C16H18ClN9O5S3
- Molecular Weight: 548.01
- MDL number: MFCD01750403
- EINECS: 278-299-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 15:53:33
What is Cefmenoxime hydrochloride ?
Description
Cef menoxime hydrochloride is a third generation cephalosporin antibiotic. Structurally, it possesses the (1-methyl-lH-tetrazol-5-yl)thiomethyl moiety in the 3-position; like several other compounds containing this structural element (moxalactam, cefoperazone, cefamandol), bleeding linked to vitamin K interaction has been reported. Cefmenoxime has activity similar to cefotiuime, ceftizoxime and moxalactam against E.coli, C. diversus, Klebsiella, P. Mirabilis, Salmonella, Shigella, Neiseria spp., S. pyogenes, S. Pneumoniae, and g. influenzae. It is relatively ineffective against Pseudomonas and Bacteroidea.
Originator
Takeda (Japan)
The Uses of Cefmenoxime hydrochloride
A third generation cephalosporin antibiotic with strong antimicrobial activities against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella subgenus Branhamella catarrhalis that were 3 major aerobic bacteria from sinusitis.
The Uses of Cefmenoxime hydrochloride
antibacterial
What are the applications of Application
Cefmenoxime hydrochloride is an antibacterial
Definition
ChEBI: The hemihydrochloride salt of cefmenoxime.
brand name
Cefmax (TAP);TACEF;BESTCALL.
General Description
Cefmenoxime was synthesized by Takeda Pharmaceutical Co. in 1978. It contains aminothiazole and methoxyimino groups in the 7-acyl position and a methyltetrazole group at the 3 position of the cephem nucleus. Cefmenoxime has a wide activity spectrum against gram-positive and gram-negative bacteria, including anaerobes, except Staphylococcus aureus. Cefmenoxime is a member of the so-called third-generation cephalosporins, a recently introduced class of clinically important antibiotics.
Properties of Cefmenoxime hydrochloride
Melting point: | >175°C (dec.) |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
form | Solid |
color | Off-White to Pale Yellow |
Safety information for Cefmenoxime hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Cefmenoxime hydrochloride
InChIKey | HZYJYGJIOCXOTH-AJVJENPNNA-N |
SMILES | C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC)C(=O)N12)CSC1=NN=NN1C)(=O)O.Cl |&1:5,7,r| |
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