Methoxyacetic acid

Synonym(s):NSC 7300

CAS NO.：625-45-6
Empirical Formula: C3H6O3
Molecular Weight: 90.08
MDL number: MFCD00004308
EINECS: 210-894-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:15:30

What is Methoxyacetic acid?

Chemical properties

CLEAR COLOURLESS TO VERY SLIGHTLY YELLOW LIQUID

The Uses of Methoxyacetic acid

Methoxyacetic acid is used in zebrafish embryotoxicity test to evaluate chemical toxicity after exposure of the complete vertebrate embryo during embryogenesis. It is also used in industry as gelling, viscosity and stabilizer reagent.

Definition

ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a methoxy group.

General Description

Colorless liquid.

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

Methoxyacetic acid is incompatible with alkalis and metals.

Health Hazard

ACUTE/CHRONIC HAZARDS: Methoxyacetic acid is corrosive.

Fire Hazard

Methoxyacetic acid is combustible.

Safety Profile

Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Synthesis

Methoxyacetic acid is prepared from Monochloroacetic acid with Sodium methylate.

Purification Methods

Fractionally crystallise the acid by repeated partial freezing, then fractionally distil it under vacuum through a vacuum-jacketed Vigreux column ~20cm long (p 11). [Beilstein 3 IV 574.]

Properties of Methoxyacetic acid

Melting point:	7-9 °C (lit.)
Boiling point:	202-204 °C (lit.)
Density	1.174 g/mL at 25 °C (lit.)
refractive index	n20/D 1.417(lit.)
Flash point:	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Methanol (Slightly); Soluble in water, alcohol and oils.
form	Liquid
pka	pK1:3.57 (25°C)
color	Clear colorless to very slightly yellow
PH	1.6 (100g/l, H2O)
Odor	Peculiar fatty vinegear-like odor, in dilution fairly pleasant.
Water Solubility	freely soluble
Sensitive	Hygroscopic
BRN	635800
CAS DataBase Reference	625-45-6(CAS DataBase Reference)
NIST Chemistry Reference	Acetic acid, methoxy-(625-45-6)
EPA Substance Registry System	Methoxyacetic acid (625-45-6)

Safety information for Methoxyacetic acid

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H314:Skin corrosion/irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P201:Obtain special instructions before use. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.