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HomeProduct name listCarvacrol

Carvacrol

Synonym(s):2-Methyl-5-isopropylphenol, Isothymol, Carvacrol;5-Isopropyl-2-methylphenol

  • CAS NO.:499-75-2
  • Empirical Formula: C10H14O
  • Molecular Weight: 150.22
  • MDL number: MFCD00002236
  • EINECS: 207-889-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:15:30
Carvacrol Structural

What is Carvacrol?

Chemical properties

liquid

Chemical properties

Carvacrol has a characteristic pungent, warm odor. The commercial product consists of a mixture of isomers differing because of the position of the isopropyl radical. The odor characteristics differ between the technical (lower grade) and pure (higher grade) commercial products.

Occurrence

Reported found in cumin seed, thyme, oregano, calamus, lovage, myrtle and lemon balm.

The Uses of Carvacrol

Reference Standard in the analysis of herbal medicinal products

The Uses of Carvacrol

Carvacrol is a flavoring agent that is a colorless to pale yellow liquid. it has a spicy and pungent odor, resembling thymol. it is insoluble in water and soluble in alcohol and ether. it is a mixture of the isomeric carvacrols (isopropyl o-creols), and is obtained by chemical synthesis. it is also an ingredient of savory, a fragrant herb in nature.

The Uses of Carvacrol

As disinfectant; in organic syntheses.

Definition

ChEBI: A phenol that is a natural monoterpene derivative of cymene. An inhibitor of bacterial growth, it is used as a food additive. Potent activator of the human ion channels transient receptor potential V3 (TRPV3) and A1 (TRPA1).

Preparation

From p-cymene by sulfonation and subsequent alkali fusion.

Aroma threshold values

Detection at 2.29 ppm.

Taste threshold values

Taste characteristics at 5.0 ppm: spicy, herbal phenolic, medicinal and woody.

Synthesis Reference(s)

Tetrahedron Letters, 19, p. 2545, 1978 DOI: 10.1016/S0040-4039(01)94822-1

General Description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Flammability and Explosibility

Not classified

Safety Profile

Poison by ingestion, intravenous, and subcutaneous routes. Moderately toxic by skin contact. A severe skin irritant. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes.

Properties of Carvacrol

Melting point: 3-4 °C(lit.)
Boiling point: 236-237 °C(lit.)
Density  0.976 g/mL at 20 °C(lit.)
vapor pressure  3.09-6.664Pa at 25℃
refractive index  n20/D 1.522(lit.)
FEMA  2245 | CARVACROL
Flash point: 224 °F
storage temp.  -20°C
solubility  1.25g/l
form  neat
pka 10.38±0.10(Predicted)
form  Liquid
color  Colorless to Light orange to Yellow
Odor Penetrating, dry-medicinal (“-phenolic”) - herbaceous odor with a spicy undertone.
Water Solubility  Insoluble
JECFA Number 710
Merck  14,1872
BRN  1860514
Stability: Stable. Combustible. Incompatible with strong bases, strong oxidizing agents.
CAS DataBase Reference 499-75-2(CAS DataBase Reference)
NIST Chemistry Reference Phenol, 2-methyl-5-(1-methylethyl)-(499-75-2)
EPA Substance Registry System Isopropyl-o-cresol (499-75-2)

Safety information for Carvacrol

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
ghs
Environment
GHS09
GHS Hazard Statements H302:Acute toxicity,oral
H314:Skin corrosion/irritation
H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P270:Do not eat, drink or smoke when using this product.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Carvacrol

InChIKey RECUKUPTGUEGMW-UHFFFAOYSA-N

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