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HomeProduct name listCARBOCROMEN

CARBOCROMEN

  • CAS NO.:804-10-4
  • Empirical Formula: C20H27NO5
  • Molecular Weight: 361.43
  • MDL number: MFCD00868244
  • EINECS: 212-356-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:42
CARBOCROMEN Structural

What is CARBOCROMEN?

Originator

Intensain,Hoechst,Switz,1963

The Uses of CARBOCROMEN

Vasodilator (coronary).

Background

Carbocromen was marketed for use in Germany as a vasodilator, however, it has been discontinued due to the risk of arrhythmia development .

Definition

ChEBI: Carbocromen is a member of coumarins.

Manufacturing Process

18.7 g of 3β-diethylaminoethyl-4-methyl-7-hydroxy-coumarin chlorhydrate are dissolved in 200 cc methyl ethyl ketone and 18 g anhydrous potassium carbonate are added. The mixture is stirred for 1 hour at 70°C and then 12 g bromoacetic acid ethyl ester are allowed to drop in. The reaction mixture is stirred under reflux for 9 hours and then it is filtered off with suction in the heat. The filtrate is concentrated in the vacuum to dryness and the resultant
residue is dissolved in ether. The etheric solution is washed with diluted caustic soda solution for several times and, subsequently, dried with Glauber's salt. By introduction of hydrochloric acid gas into the etheric solution the reaction product is precipitated in the form of chlorhydrate. Yield: 15 g of 3β- diethylaminoethyl-4-methylcoumarin-7-ethyl oxyacetate chlorhydrate having a melting point of 154° to 156°C (= 63% of the theory).
The starting material is produced by reacting resorcinol with 2-(2- diethylaminoethyl)acetic acid ethyl ester.

Therapeutic Function

Coronary vasodilator

Metabolism

Not Available

Properties of CARBOCROMEN

Melting point: 220-222 °C
Boiling point: 488.6±45.0 °C(Predicted)
Density  1.126±0.06 g/cm3(Predicted)
storage temp.  Refrigerator, under inert atmosphere
solubility  Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form  Solid
pka pKa 8.3 (Uncertain)
color  Off-White

Safety information for CARBOCROMEN

Computed Descriptors for CARBOCROMEN

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