PILSICAINIDE
- CAS NO.:88069-67-4
- Empirical Formula: C17H24N2O
- Molecular Weight: 272.39
- MDL number: MFCD00864748
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:43
What is PILSICAINIDE?
Chemical properties
Pilsicainide: C17H24N2O?HCl?1/2H20. [88069-49-2]. It is obtained from the crystallization of ethanol-diethyl ether. Odorless, bitter taste, melting point 212 ~ 214℃. It is highly soluble in glacial acetic acid and soluble in methanol, ethanol or water.
The Uses of PILSICAINIDE
Pilsicainide is a class IC antiarrhythmic drug, suitable for the treatment of patients with ventricular tachycardia ineffective or intolerable to other antiarrhythmic drugs.
Definition
ChEBI: Pilsicainide is a secondary carboxamide resulting from the formal condensation of the amino group of 2,6-dimethylaniline with the carboxy group of (tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetic acid. It is a sodium channel blocker which is used as an antiarrhythmic drug for the management of atrial tachyarrhythmias in Japan. It has a role as an anti-arrhythmia drug and a sodium channel blocker. It is a secondary carboxamide and an organic heterobicyclic compound.
Synthesis
Pilsicainide was obtained from tetrahydrodithickened pyrrole ethyl acetate and 2, 6-dimethylaniline heated and condensed in dioxane at 100℃ under the action of sodium hydride. It is also possible to hydrolyze tetrahydrodithickened pyrrole ethyl acetate and chlorinate it to tetrahydrodithickened pyrrole acetyl chloride, which is then condensed with 2, 6-dimethylaniline.
Properties of PILSICAINIDE
storage temp. | Sealed in dry,2-8°C |
Safety information for PILSICAINIDE
Computed Descriptors for PILSICAINIDE
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin C Tubulysin H 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Calcium Sodium Phosphosilicate IH Methyl 4-amino-3-(pyrrolidin-1-yl)benzoate Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester 4,8-dibromo-5H-[1,2,3]triazolo[4',5':4,5]benzo[1,2-c][1,2,5]thiadiazole 3-Morpholino-5,6-dihydropyridin-2(1H)-one Methyl 4-amino-3-(piperidin-1-yl)benzoate 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 5-Bromo-4,6-difluoro-2,3-dihydro-1h-indole 3-HYDROXY-8-FLUORONAPHTHALENE-1-BORONIC ACID PINACOL ESTER ((E)-3-(Dimethylamino)-2-methylacrylaldehyde (±)-1-Phenylethane ethane sulfonic acid ert-butyl 3-[(prop-2-yn-1-yl)amino]propanoateRelated products of tetrahydrofuran
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