CALYCULIN A

Synonym(s):Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem;InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem

CAS NO.：101932-71-2
Empirical Formula: C50H81N4O15P
Molecular Weight: 1009.17
MDL number: MFCD06795864
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-13 18:13:23

What is CALYCULIN A?

The Uses of CALYCULIN A

Calyculin A is a PP1 and PP2A-C inhibitor and tumor inducer.

The Uses of CALYCULIN A

Inhibitor of phosphatases 1 and 2a.

The Uses of CALYCULIN A

Calyculin A from Discodermia calyx has been used:

as an inhibitor of serine-threonine protein phosphatase 2A
as an inhibitor of cyclin D1 phosphatase in human breast cancer cells
as an inhibitor of protein phosphatase 2A (PP2A) and PP1 in mouse melanoma cell lines B16-F0 cells

What are the applications of Application

Calyculin A is a cell-permeable inhibitor of phosphatase 1 (PP1) and protein phosphatase 2A (PP2A-C), and may promote tumor growth

General Description

Calyculin A is derived from the marine sponge Discodermia calyx. It corresponds to a molecular weight of 1008 Da.

Biological Activity

Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC 50 = 0.3-0.7 nM) and protein phosphatase 2A (IC 50 = 0.5-1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.

Biochem/physiol Actions

Inhibitor of protein phosphatases types 1 and 2A; marine toxin, potent tumor promotor.

storage

Store at -20°C

Properties of CALYCULIN A

Melting point:	247-249°
alpha	D -60° (c = 0.1 in ethanol)
Density	1.25±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: soluble
pka	1.81±0.10(Predicted)
form	solid
color	white
Water Solubility	Soluble in DMSO (50 mM), ethanol (1 mg/ml), methanol, acetone, acetonitrile, chloroform, methylene chloride, and benzene. Insoluble in water.
Merck	13,1731
BRN	4903216

Safety information for CALYCULIN A

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H315:Skin corrosion/irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.