CALYCULIN A
Synonym(s):Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem;InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem
- CAS NO.：101932-71-2
- Empirical Formula: C50H81N4O15P
- Molecular Weight: 1009.17
- MDL number: MFCD06795864
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-13 18:13:23
What is CALYCULIN A?
The Uses of CALYCULIN A
Calyculin A is a PP1 and PP2A-C inhibitor and tumor inducer.
The Uses of CALYCULIN A
Inhibitor of phosphatases 1 and 2a.
The Uses of CALYCULIN A
Calyculin A from Discodermia calyx has been used:
- as an inhibitor of serine-threonine protein phosphatase 2A
- as an inhibitor of cyclin D1 phosphatase in human breast cancer cells
- as an inhibitor of protein phosphatase 2A (PP2A) and PP1 in mouse melanoma cell lines B16-F0 cells
What are the applications of Application
Calyculin A is a cell-permeable inhibitor of phosphatase 1 (PP1) and protein phosphatase 2A (PP2A-C), and may promote tumor growth
General Description
Calyculin A is derived from the marine sponge Discodermia calyx. It corresponds to a molecular weight of 1008 Da.
Biological Activity
Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC 50 = 0.3-0.7 nM) and protein phosphatase 2A (IC 50 = 0.5-1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.
Biochem/physiol Actions
Inhibitor of protein phosphatases types 1 and 2A; marine toxin, potent tumor promotor.
storage
Store at -20°C
Properties of CALYCULIN A
| Melting point: | 247-249° |
| alpha | D -60° (c = 0.1 in ethanol) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| pka | 1.81±0.10(Predicted) |
| form | solid |
| color | white |
| Water Solubility | Soluble in DMSO (50 mM), ethanol (1 mg/ml), methanol, acetone, acetonitrile, chloroform, methylene chloride, and benzene. Insoluble in water. |
| Merck | 13,1731 |
| BRN | 4903216 |
Safety information for CALYCULIN A
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for CALYCULIN A
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