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HomeProduct name listCALYCULIN A

CALYCULIN A

Synonym(s):Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem;InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem

CALYCULIN A Structural

What is CALYCULIN A?

The Uses of CALYCULIN A

Calyculin A is a PP1 and PP2A-C inhibitor and tumor inducer.

The Uses of CALYCULIN A

Inhibitor of phosphatases 1 and 2a.

The Uses of CALYCULIN A

Calyculin A from Discodermia calyx has been used:

  • as an inhibitor of serine-threonine protein phosphatase 2A
  • as an inhibitor of cyclin D1 phosphatase in human breast cancer cells
  • as an inhibitor of protein phosphatase 2A (PP2A) and PP1 in mouse melanoma cell lines B16-F0 cells

What are the applications of Application

Calyculin A is a cell-permeable inhibitor of phosphatase 1 (PP1) and protein phosphatase 2A (PP2A-C), and may promote tumor growth

General Description

Calyculin A is derived from the marine sponge Discodermia calyx. It corresponds to a molecular weight of 1008 Da.

Biological Activity

Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC 50 = 0.3-0.7 nM) and protein phosphatase 2A (IC 50 = 0.5-1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.

Biochem/physiol Actions

Inhibitor of protein phosphatases types 1 and 2A; marine toxin, potent tumor promotor.

storage

Store at -20°C

Properties of CALYCULIN A

Melting point: 247-249°
alpha  D -60° (c = 0.1 in ethanol)
Density  1.25±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO: soluble
pka 1.81±0.10(Predicted)
form  solid
color  white
Water Solubility  Soluble in DMSO (50 mM), ethanol (1 mg/ml), methanol, acetone, acetonitrile, chloroform, methylene chloride, and benzene. Insoluble in water.
Merck  13,1731
BRN  4903216

Safety information for CALYCULIN A

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H315:Skin corrosion/irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for CALYCULIN A

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