MICROCYSTIN YR

Synonym(s):Algae bloom toxin;Biotoxin;Cyanobacterial toxin

CAS NO.：101064-48-6
Empirical Formula: C52H72N10O13
Molecular Weight: 1045.19
MDL number: MFCD00236437
EINECS: 621-458-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is MICROCYSTIN YR?

The Uses of MICROCYSTIN YR

Microcystin YR from Microcystis aeruginosa has been used to assess cytotoxicity in neutrophils using DNA fragmentation and cell viability assays and as a reference standard in the quantification of microcystin from water samples.

General Description

Microcystin is a potent cyanotoxin produced by the bloom of Microcystis aeruginosa. It is harmful to aquatic animals. It is a heptapeptide and exists as multiple variant forms. pCO₂ and nitrogen levels modulate the toxic variants levels. It elicits damage to the liver and other organs.

Biochem/physiol Actions

Microcystin YR inhibits protein phosphatase type 2A and protein phosphatase type 1. Toxicity to undifferentiated cells was seen by inhibition of neutral red uptake, >80% at 100 μM, after 48 h.

Properties of MICROCYSTIN YR

Density	1.33±0.1 g/cm3(Predicted)
Flash point:	11 °C
storage temp.	−20°C
solubility	methanol: 2 mg/mL (further dilute to 10% (v/v) methanol)
pka	3.02±0.70(Predicted)
form	white powder
EPA Substance Registry System	Cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-tyrosyl-(3S)-3-methyl-D-.beta.-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-.gamma.-glutamyl] (101064-48-6)

Safety information for MICROCYSTIN YR

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H225:Flammable liquids H300:Acute toxicity,oral H301:Acute toxicity,oral H310:Acute toxicity,dermal H311:Acute toxicity,dermal H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H330:Acute toxicity,inhalation H331:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302+P350:IF ON SKIN: Gently wash with plenty of soap and water.