NODULARIN

Synonym(s):1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;Nodularin-R solution

CAS NO.：118399-22-7
Empirical Formula: C41H60N8O10
Molecular Weight: 824.96
MDL number: MFCD16659855
EINECS: 621-437-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-06 08:46:17

What is NODULARIN?

Description

The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC₅₀ values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC₅₀ of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.

The Uses of NODULARIN

Nodularin-R is a cyclic peptide toxin produced by freshwater cyanobacteria.

Definition

Toxin produced by blue green algae.

Properties of NODULARIN

Density	1.29±0.1 g/cm3(Predicted)
Flash point:	11℃
storage temp.	−20°C
solubility	methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.
form	Dry residue containing traces of monobasic potassium phosphate.
pka	3.39±0.70(Predicted)
IARC	3 (Vol. 94) 2010
EPA Substance Registry System	Nodularin (118399-22-7)

Safety information for NODULARIN

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.