NODULARIN
Synonym(s):1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;Nodularin-R solution
- CAS NO.：118399-22-7
- Empirical Formula: C41H60N8O10
- Molecular Weight: 824.96
- MDL number: MFCD16659855
- EINECS: 621-437-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-06 08:46:17
What is NODULARIN?
Description
The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.
The Uses of NODULARIN
Nodularin-R is a cyclic peptide toxin produced by freshwater cyanobacteria.
Definition
Toxin produced by blue green algae.
Properties of NODULARIN
| Density | 1.29±0.1 g/cm3(Predicted) |
| Flash point: | 11℃ |
| storage temp. | −20°C |
| solubility | methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months. |
| form | Dry residue containing traces of monobasic potassium phosphate. |
| pka | 3.39±0.70(Predicted) |
| IARC | 3 (Vol. 94) 2010 |
| EPA Substance Registry System | Nodularin (118399-22-7) |
Safety information for NODULARIN
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NODULARIN
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