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HomeProduct name listC6-NBD-CERAMIDE

C6-NBD-CERAMIDE

C6-NBD-CERAMIDE Structural

What is C6-NBD-CERAMIDE?

Description

C6 NBD ceramide is a biologically active fluorescent analog of short chain, membrane-permeable ceramides. It is as effective as C6 ceramide in the inhibition of viral glycoprotein transport through the Golgi. C6 NBD ceramide has been used as a fluorescent substrate for the activity of UDP-glucose:ceramide glucosyltransferase and to demonstrate the translocation of glucocerebroside and sphingomyelin from the Golgi to the plasma membrane.

Chemical properties

Rust or Dark Yellow Solid

The Uses of C6-NBD-CERAMIDE

A vital fluoresent stain for the Golgi apparatus.

Definition

ChEBI: N-{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl}sphingosine is an N-acylsphingosine that is sphingosine with the amino nitrogen converted into a 6-{[N-(7-nitrobenzo-2,1,3-oxadiazol-4-yl)amino]}hexananamido group. It has a role as a fluorescent probe.

References

Chazotte (2012),?Labeling Golgi with Fluorescent Ceramides;?Cold Spring Harb. Protoc. (8):pdb.prot070599 van Meer et al. (1987),?Sorting of sphingolipids in epithelial (Madin-Darby canine kidney) cells; J. Cell Biol.?105 1623 Don and Rosen (2008),?A fluorescent plate reader assay for ceramide kinase; Anal. Biochem.?375 265 Nikolova-Karakashian (2021),?Methods to Characterize Synthesis and Degradation of Sphingomyelin at the Plasma Membrane and Its Impact on Lipid Raft Dynamics; Methods Mol. Biol.?2187 113

Properties of C6-NBD-CERAMIDE

Melting point: 85-88 °C
Density  1.153±0.06 g/cm3(Predicted)
storage temp.  −20°C
solubility  Soluble in DMSO (35 mg/mL)
form  solid
pka 13.54±0.20(Predicted)
color  Orange
Stability: Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety information for C6-NBD-CERAMIDE

Computed Descriptors for C6-NBD-CERAMIDE

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