9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
- CAS NO.:1124329-14-1
- Empirical Formula: C24H32N6O3
- Molecular Weight: 452.55
- MDL number: MFCD18384959
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one?
Description
AZ3146 (1124329-14-1) is a potent (IC50?= 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1?Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).2
The Uses of 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
AZ 3146 is a protein kinase Mps1 inhibitor.
What are the applications of Application
AZ 3146 is a potent and selective TTK (monopolar spindle 1 (Mps1) kinase) inhibitor
storage
Store at +4°C
References
1) Hewitt?et al. (2010)?Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex; J. Cell Biol.?190?25 2) Liu?et al.?(2015)?TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells; Oncotarget?6?34309
Properties of 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
Boiling point: | 621.0±65.0 °C(Predicted) |
Density | 1.279 |
storage temp. | Store at +4°C |
solubility | Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml) |
form | solid |
pka | 8.29±0.10(Predicted) |
color | Off-white |
Stability: | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
Safety information for 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
Computed Descriptors for 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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