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HomeProduct name listBUTYROLACTONE I

BUTYROLACTONE I

Synonym(s):Butyrolactone I - CAS 87414-49-1 - Calbiochem

BUTYROLACTONE I Structural

What is BUTYROLACTONE I?

The Uses of BUTYROLACTONE I

Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I exhibits antitumor activity, inhibiting the cell cycle at the G1/S and G2/M transitions. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.

What are the applications of Application

Butyrolactone I is an exogenous inhibitor of CDK cyclin-dependent kinases

Enzyme inhibitor

This natural product (FW = 424.45 g/mol), first identified in species of Aspergillus and named systematically as 2,5-dihydro-4-hydroxy 2-([4- hydroxy-3-(3-methyl-2-butenyl)phenyl]methyl)-3-(4-hydroxyphenyl)-5-oxo- 2-furancarboxylic acid methyl ester, competes with ATP in cyclindependent kinase reactions. The IC50 values for these kinases are typically 0.6-1.5 μM. Butyrolactone I also inhibits cell proliferation by the inhibiting pRb phosphorylation in IMR32 cells, causing both G1 and G2 arrest and stimulating apoptosis. Target(s): cyclin-dependent kinases 1 and 2; cdk5; protein kinase C; protein kinase A; MAP kinase; casein kinase II; [tau protein] kinase.

storage

+4°C

Properties of BUTYROLACTONE I

Melting point: 74℃
Boiling point: 660.1±55.0 °C(Predicted)
Density  1.353±0.06 g/cm3(Predicted)
RTECS  LU0221600
storage temp.  Store at -20°C
solubility  Soluble in ethanol at 25mg/ml or DMSO at 10mg/ml
form  White solid.
pka 8.59±0.40(Predicted)
color  White to off-white
Sensitive  Light Sensitive

Safety information for BUTYROLACTONE I

Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for BUTYROLACTONE I

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