BUTYROLACTONE I
Synonym(s):Butyrolactone I - CAS 87414-49-1 - Calbiochem
- CAS NO.:87414-49-1
- Empirical Formula: C24H24O7
- Molecular Weight: 424.44
- MDL number: MFCD03453074
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 18:15:48
What is BUTYROLACTONE I?
The Uses of BUTYROLACTONE I
Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I exhibits antitumor activity, inhibiting the cell cycle at the G1/S and G2/M transitions. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.
What are the applications of Application
Butyrolactone I is an exogenous inhibitor of CDK cyclin-dependent kinases
Enzyme inhibitor
This natural product (FW = 424.45 g/mol), first identified in species of Aspergillus and named systematically as 2,5-dihydro-4-hydroxy 2-([4- hydroxy-3-(3-methyl-2-butenyl)phenyl]methyl)-3-(4-hydroxyphenyl)-5-oxo- 2-furancarboxylic acid methyl ester, competes with ATP in cyclindependent kinase reactions. The IC50 values for these kinases are typically 0.6-1.5 μM. Butyrolactone I also inhibits cell proliferation by the inhibiting pRb phosphorylation in IMR32 cells, causing both G1 and G2 arrest and stimulating apoptosis. Target(s): cyclin-dependent kinases 1 and 2; cdk5; protein kinase C; protein kinase A; MAP kinase; casein kinase II; [tau protein] kinase.
storage
+4°C
Properties of BUTYROLACTONE I
Melting point: | 74℃ |
Boiling point: | 660.1±55.0 °C(Predicted) |
Density | 1.353±0.06 g/cm3(Predicted) |
RTECS | LU0221600 |
storage temp. | Store at -20°C |
solubility | Soluble in ethanol at 25mg/ml or DMSO at 10mg/ml |
form | White solid. |
pka | 8.59±0.40(Predicted) |
color | White to off-white |
Sensitive | Light Sensitive |
Safety information for BUTYROLACTONE I
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for BUTYROLACTONE I
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