Flavopiridol
- CAS NO.:146426-40-6
- Empirical Formula: C21H20ClNO5
- Molecular Weight: 401.84
- MDL number: MFCD20501884
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:16
What is Flavopiridol?
The Uses of Flavopiridol
Antineoplastic (cyclin-dependent kinase inhibitor)[Note—The trivial name, flavopiridol, has appeared in literature].
The Uses of Flavopiridol
Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs. Inhibitor of CDK9 as a postexposure drug target for adenoviruses.
What are the applications of Application
Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs
Definition
ChEBI: Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antirheumatic drug and an apoptosis inducer. It is a dihydroxyflavone, a hydroxypiperidine, a member of monochlorobenzenes and a tertiary amino compound. It is a conjugate base of an alvocidib(1+).
Anticancer Research
It is a synthetic derivative of rohitukine plant alkaloid which is obtained fromDysoxylum binectariferum, which is active against leukemia, lymphomas and solidtumors (Shoeb 2006).
Properties of Flavopiridol
Melting point: | 52.5 °C |
Boiling point: | 603.6±55.0 °C(Predicted) |
Density | 1.448±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic |
pka | 6.16±0.40(Predicted) |
form | Yellow powder. |
color | Light yellow to yellow |
CAS DataBase Reference | 146426-40-6(CAS DataBase Reference) |
Safety information for Flavopiridol
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Flavopiridol
InChIKey | BIIVYFLTOXDAOV-YVEFUNNKSA-N |
SMILES | C1(C2=CC=CC=C2Cl)OC2=C([C@H]3CCN(C)C[C@H]3O)C(O)=CC(O)=C2C(=O)C=1 |
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