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HomeProduct name listBML-259

BML-259

BML-259 Structural

What is BML-259?

Description

BML-259 (267654-00-2) is a potent inhibitor of Cdk5/p25 (IC50 = 64 nM) and Cdk2 (IC50 = 98nM).1

What are the applications of Application

BML-259 is a potent inhibitor of CDK5 & CDK2/cyclin E

Definition

ChEBI: 2-phenyl-N-(5-propan-2-yl-2-thiazolyl)acetamide is a member of acetamides.

References

1) Helal et al. (2004) Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease; Bioorg. Med. Chem. Lett. 14 5521

Properties of BML-259

Melting point: 150-152℃
storage temp.  RT
solubility  Soluble in DMSO (up to 25 mg/ml).
form  White solid.
color  white
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety information for BML-259

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for BML-259

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