NU 2058
- CAS NO.：161058-83-9
- Empirical Formula: C12H17N5O
- Molecular Weight: 247.3
- MDL number: MFCD05664734
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is NU 2058?
Description
NU 2058 is an inhibitor of cyclin-dependent kinase 1 (Cdk1) and Cdk2 (IC50s = 7.0 and 17 μM, respectively). Increased Cdk activity is often associated with human tumors, and inhibitors of Cdks, including NU 2058, can arrest cell cycling in cancer cells in vitro.
The Uses of NU 2058
NU 2058 is an intermediate of NU 6140 (N925295), a cyclin-dependant kinase 2 inhibitor which demonstrates 10-36 fold selectivity against Cdk2-cyclin A. This selectivity induces cell-cycle arrest at the G2-M phase and potentiates the apoptotic effect of pacitaxel.
What are the applications of Application
NU2058 is a CDK1, CDK2, and Topo II inhibitor
Biological Activity
Cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (K i values are 5 and 12 μ M respectively). Inhibits growth of human tumor cells in vitro (mean GI 50 = 13 μ M). Also inhibits DNA topoisomerase II ATPase activity (IC 50 = 300 μ M).
storage
Store at +4°C
Properties of NU 2058
| Melting point: | 199°C(lit.) |
| Boiling point: | 424.8±55.0 °C(Predicted) |
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO: 22 mg/mL |
| pka | 7.36±0.20(Predicted) |
| form | powder to crystal |
| color | white |
| λmax | 281nm(MeOH)(lit.) |
Safety information for NU 2058
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NU 2058
| InChIKey | MWGXGTJJAOZBNW-UHFFFAOYSA-N |
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