butizide
- CAS NO.:2043-38-1
- Empirical Formula: C11H16ClN3O4S2
- Molecular Weight: 353.85
- MDL number: MFCD00867351
- EINECS: 218-048-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:35
What is butizide?
Chemical properties
Off-White Solid
Originator
Saltucin,Boehringer Mannheim,W. Germany,1961
The Uses of butizide
Diuretic and antihypertensive.
Definition
ChEBI: Butizide is a benzothiadiazine.
Manufacturing Process
Chlorsulfonic acid and 3-chloroaniline react to give an intermediate which
when treated with ammonia yields 5-chloro-2,4-disulfamylaniline.
20 g of 5-chloro-2,4-disulfamylaniline in 15 cc of diethyleneglycol-dimethyl
ether with 0.9 g of isovaleraldehyde are reacted in the presence of 0.5 cc of a
saturated solution of hydrochloric acid in ethyl acetate at 80°-90°C. The
reaction mixture is concentrated under reduced pressure, an oily product
precipitates on the addition of water, the latter is decanted and ethanol added
to the remaining oil. 3-Isobutyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-
benzothiadiazine-1,1-dioxide crystallizes and, after recrystallization from
dimethylformamide and water, melts at 241°-245°C.
Therapeutic Function
Diuretic, Antihypertensive
Properties of butizide
Melting point: | 214-217°C |
Boiling point: | 562.7±60.0 °C(Predicted) |
Density | 1.4221 (rough estimate) |
refractive index | 1.6100 (estimate) |
storage temp. | Refrigerator |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 9.01±0.40(Predicted) |
color | White to Yellow |
Safety information for butizide
Computed Descriptors for butizide
New Products
2,2-diethoxyethanethioamide Tubulysin B Tubulysin C Tubulysin G Potassium HMDS (1.0 M in THF) 4-(Benzyloxy)-3-bromophenylacetic Acid 4,4-DIFLUOROPIPERIDINE Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 4,4-DIFLUOROCYCLOHEXANAMINE Fuel shell Imeglimin Hydrochloride IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
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