ethiazide
- CAS NO.：1824-58-4
- Empirical Formula: C9H12ClN3O4S2
- Molecular Weight: 325.79
- MDL number: MFCD00867314
- EINECS: 217-358-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is ethiazide?
Originator
Ethiazide,Tokyo Tanabe,Japan,1970
Definition
ChEBI: Ethiazide is a benzothiadiazine.
Manufacturing Process
A mixture of 2.9 grams of 5-chloro-2,4-disulfamyl-aniline in 20 ml of anhydrous diethylene glycoldimethylether, 0.44 gram of propionaldehyde and 0.5 ml of a solution of hydrogen chloride in ethyl acetate (109.5 grams hydrogen chloride per 1,000 ml) is heated to 80° to 90°C and maintained at that temperature for 1 hour. The reaction mixture is concentrated under reduced pressure; on addition of water, the product separates and is then recrystallized from ethanol or aqueous ethanol to yield the desired 6-chloro-3- ethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide, MP 269° to 270°C.
Therapeutic Function
Diuretic, Cardiotonic, Smooth muscle relaxant, Respiratory stimulant
Properties of ethiazide
| Melting point: | 269-270° |
| Boiling point: | 563.5±60.0 °C(Predicted) |
| Density | 1.526±0.06 g/cm3(Predicted) |
| pka | 9.01±0.40(Predicted) |
Safety information for ethiazide
Computed Descriptors for ethiazide
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