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HomeProduct name listButamyrate

Butamyrate

  • CAS NO.:18109-80-3
  • Empirical Formula: C18H29NO3
  • Molecular Weight: 307.431
  • MDL number: MFCD00827785
  • EINECS: 242-005-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
Butamyrate Structural

What is Butamyrate?

Originator

Sinecod,Hommel,Switz.,1967

The Uses of Butamyrate

Antitussive.

Definition

ChEBI: Butamirate is an alkylbenzene.

Manufacturing Process

18.2 grams of α-phenylbutyric acid chloride are dissolved in 25 ml of toluene. To this solution, there is slowly added a solution of 16.1 grams of diethylaminoethoxyethanol in 25 ml of toluene, the reaction mixture thereby becoming hot. It is then heated for 8 hr under reflux. The reaction mixture, after cooling, is carefully poured onto 75 grams of ice and made alkaline with dilute ammonia. After thorough shaking of the solution, the toluene layer is removed and washed until neutral with water. The toluene solution is treated with carbon and dried over sodium sulfate. The toluene is distilled off from the filtered solution.
The residue is α-phenylbutyric acid diethylaminoethoxyethyl ester. The basic ester is purified by distillation in a high vacuum. 10 grams of ester are added to a solution of 7 grams of citric acid in 30 ml of warm acetone. After standing for some time, the citrate of the ester crystallizes out. After suction filtration and washing with acetone the ester citrate is recrystallized from acetone. The melting point of the citrate is 75°C.

Therapeutic Function

Antitussive

Properties of Butamyrate

Melting point: <25 °C
Boiling point: bp1 140-155°
Density  1.007±0.06 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Oil
pka 9.68±0.25(Predicted)
color  Clear Colourless to Dark Yellow

Safety information for Butamyrate

Computed Descriptors for Butamyrate

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