Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listButamirate citrate

Butamirate citrate

  • CAS NO.:18109-81-4
  • Empirical Formula: C24H37NO10
  • Molecular Weight: 499.55128
  • MDL number: MFCD00315222
  • EINECS: 242-006-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
Butamirate citrate Structural

What is Butamirate citrate?

Chemical properties

White Solid

Originator

Sinecod,Hommel,Switz.,1967

The Uses of Butamirate citrate

Butamirate Citrate is a novel antitussive drug. It is used for the symptomatic treatment of non-productive (dry) cough.

The Uses of Butamirate citrate

Anxiolytic, Muscle Relaxant

What are the applications of Application

Butamirate Citrate is an amine used for research purposes only

Manufacturing Process

18.2 grams of α-phenylbutyric acid chloride are dissolved in 25 ml of toluene. To this solution, there is slowly added a solution of 16.1 grams of diethylaminoethoxyethanol in 25 ml of toluene, the reaction mixture thereby becoming hot. It is then heated for 8 hr under reflux. The reaction mixture, after cooling, is carefully poured onto 75 grams of ice and made alkaline with dilute ammonia. After thorough shaking of the solution, the toluene layer is removed and washed until neutral with water. The toluene solution is treated with carbon and dried over sodium sulfate. The toluene is distilled off from the filtered solution.
The residue is α-phenylbutyric acid diethylaminoethoxyethyl ester. The basic ester is purified by distillation in a high vacuum. 10 grams of ester are added to a solution of 7 grams of citric acid in 30 ml of warm acetone. After standing for some time, the citrate of the ester crystallizes out. After suction filtration and washing with acetone the ester citrate is recrystallized from acetone. The melting point of the citrate is 75°C.

Therapeutic Function

Antitussive

General Description

Butamirate citrate is a non-opioid antitussive with a central effect on receptors in the brain stem. It has also been reported that it reduces bronchospasm with peripheral effect and has anti-inflammatory and anticholinergic effects. Therefore, it is thought to be effective in cough with both acute and chronic etiology.

Properties of Butamirate citrate

Melting point: 66-68°C
storage temp.  Hygroscopic, Refrigerator, Under Inert Atmosphere
solubility  Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form  Solid
color  White

Safety information for Butamirate citrate

Computed Descriptors for Butamirate citrate

InChIKey JVKMHUAWFDGPTF-UHFFFAOYSA-N
SMILES C1(C=CC=CC=1)C(CC)C(=O)OCCOCCN(CC)CC.C(O)(C(=O)O)(CC(=O)O)CC(=O)O

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.