BUSERELIN

Synonym(s):Buserelin acetate salt;des-Gly¹⁰-[D-Ser[t-Bu]⁶]-LH-RH ethylamide acetate salt;pGlu-His-Trp-Ser-Tyr-D-Ser(t-Bu)-Leu-Arg-Pro-NHEt acetate salt

CAS NO.：68630-75-1
Empirical Formula: C62H90N16O15
Molecular Weight: 1299.5
MDL number: MFCD01716229
EINECS: 636-185-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is BUSERELIN?

Description

Buserelin acetate is a potent analog of the hypothalamic hormone, luteinizing hormone-releasing hormone (LH-RH). Chronic administration of higher doses of buserelin desensitizes the pituitary, resulting in a decreased production of luteinizing hormone (LH), follicle stimulating hormone (FSH), and eventually sex steroids (testosterone in males and estradiol in females). Initial approval is for use in achieving medical castration in the treatment of advanced prostate cancer. It has also been investigated for the treatment of endometriosis, leiomyoma, precocious puberty, advanced breast cancer and infertility.

Chemical properties

White Solid

Originator

Hoechst AG (W. Germany)

The Uses of BUSERELIN

Gondadotropin-releasing hormone agonist, used to treat hormone-responsive cancers such as prostate and breast cancer. Synthetic nonapeptide agonist analog of LH-RH. Antineolpastic (hormonal).

Definition

ChEBI: Buserelin acetate is an organic molecular entity.

brand name

Suprefact (Hoechst-Roussel).

Biochem/physiol Actions

Buserelin is an LH-RH agonist.

Properties of BUSERELIN

Melting point:	186-188°C
storage temp.	-20°C
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
color	White to Off-White
Stability:	Hygroscopic

Safety information for BUSERELIN

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H360:Reproductive toxicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P308+P313:IF exposed or concerned: Get medical advice/attention.