BUCLIZINE, DIHYDROCHLORIDE
Synonym(s):1-(p-Chloro-α-phenylbenzyl)-4-(p-tert-butylbenzyl)piperazine;1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)-diethylenediamine hydrochloride;1-[(4-Chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-piperazine dihydrochloride;Buclina;Longifene
- CAS NO.:129-74-8
- Empirical Formula: C28H35Cl3N2
- Molecular Weight: 505.95
- MDL number: MFCD00242700
- EINECS: 204-962-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is BUCLIZINE, DIHYDROCHLORIDE?
Chemical properties
BUCLIZINE, DIHYDROCHLORIDE is Off-White Powder
Originator
Longifine,UCB
The Uses of BUCLIZINE, DIHYDROCHLORIDE
BUCLIZINE, DIHYDROCHLORIDE used as an antiemetic
What are the applications of Application
Buclizine, Dihydrochloride is an antihistamine used as an anti-emetic
Definition
ChEBI: Buclizine dihydrochloride is a hydrochloride salt that is obtained by reaction of buclizine with 2 equivalents of hydrogen chloride. It has a role as a central nervous system depressant, a local anaesthetic, a histamine antagonist, a cholinergic antagonist and an antiemetic. It contains a buclizine(2+).
Manufacturing Process
1 mol 4-chlorobenzhydril chloride was heated in toluene to reflux with 1 mol ethyl ester of piperazine 1-carboxylic acid at about 150°C in a presence of an excess of triethyl amine. On cooling the triethyl amine hydrochloride was filtered off, a solvent was removed in vacuum and the residue [(4-chlorophenyl)- phenyl-methyl]piperazine carboxylic acid ethyl ester was boiled straight away with potassium hydroxide in ethanol for 48 hours. After removing ethanol in vacuum to dryness, the residue was dissolved in benzene and washed with water. The benzene solution was dried, benzene removed in vacuum. The residue was distilled to give 4-chlorobezhydryl-piperazine. It had given the desired 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)- piperazine, buclizine, by a reaction with 4-tert-butylbenzyl chloride in the presence of any halogen hydrochloride acceptor (triethyl amine, sodium or potassium carbonate and so on). The obtained product had BP: 230°- 240°C/0.001 mm Hg.
brand name
Bucladin (Stuart).
Therapeutic Function
Antihistaminic, Antiallergic, Antinauseant, Tranquilizer, Appetite stimulant
General Description
Buclizine hydrochloride, l-(p-tertbutylbenzyl)-4-(p-chloro-α-phenylbenzyl)piperazinedihydrochloride (Bucladin-S), is a white to slightly yellowcrystalline powder that is insoluble in water. The highlylipid-soluble buclizine has CNS depressant, antiemetic, andantihistaminic properties. This drug has been discontinued inthe United States.
Safety Profile
Poison by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits very toxic fumes of NOx, and HCl.
Properties of BUCLIZINE, DIHYDROCHLORIDE
Melting point: | 230-240°C |
storage temp. | Inert atmosphere,2-8°C |
solubility | Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly) |
form | powder |
color | white to beige |
Stability: | Hygroscopic |
CAS DataBase Reference | 129-74-8 |
EPA Substance Registry System | Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, dihydrochloride (129-74-8) |
Safety information for BUCLIZINE, DIHYDROCHLORIDE
Computed Descriptors for BUCLIZINE, DIHYDROCHLORIDE
Abamectin manufacturer
DK Pharmachem Pvt Ltd
Fleming Laboratories Ltd
Ralington Pharma
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