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HomeProduct name list1-(4-Chlorobenzhydryl)piperazine

1-(4-Chlorobenzhydryl)piperazine

Synonym(s):(RS)-1-[(4-Chlorophenyl)phenylmethyl]piperazine;1-(4-Chlorobenzhydryl)piperazine;Norchlorcyclizine;NSC 86164

  • CAS NO.:303-26-4
  • Empirical Formula: C17H19ClN2
  • Molecular Weight: 286.8
  • MDL number: MFCD00005965
  • EINECS: 206-137-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
1-(4-Chlorobenzhydryl)piperazine Structural

What is 1-(4-Chlorobenzhydryl)piperazine?

Chemical properties

White Solid

The Uses of 1-(4-Chlorobenzhydryl)piperazine

A metabolite of Cetirizine (C281100) and Hydroxyzine. Citirizine impurity A.

The Uses of 1-(4-Chlorobenzhydryl)piperazine

Cetrizine Dihydrochloride intermediate

What are the applications of Application

1-[(4-Chlorophenyl)phenylmethyl]piperazine is a metabolite of Cetirizine and Hydroxyzine

Preparation

Preparation of 1-[(4-chlorophenyl)phenylmethyl]piperazine. (CPMP)
About 0.5 mL of DMF, 0.1 g of KI and 10 g (0.12 mol) of piperazine were mixed with 15 mL of toluene and heated to 80oC for 0.5 h. This mixture at 80oC was mixed with 4-CBC in toluene and the temperature was maintained at 80oC for a period of 2 h followed by refluxing at the same temperature for 12h. The reaction mixture was then cooled to 20oC. The toluene layer was washed twice with 20 mL of water and treated with HCl (15 mL conc. HCl in 5mL of water) at 5-10oC. The reaction mixture was filtered and the aqueous layer was separated from the filtrate. About 10 mL of toluene and 10 mL of methylene dichloride (MDC) washes were given to the aqueous layer and neutralized with 22 mL of 30 % NaOH solution at 10oC and maintained at 20oC for 2h. The solid compound formed was filtered, sucked and dried at 50oC for 3 h.Yield: 92 %; m.p: 63-65oC.

Flammability and Explosibility

Not classified

Safety Profile

An experimental teratogen.Experimental reproductive effects. When heated todecomposition it emits very toxic fumes of NOx and Clí.

Properties of 1-(4-Chlorobenzhydryl)piperazine

Melting point: 65-70 °C (lit.)
Boiling point: 178-180 °C/0.5 mmHg (lit.)
Density  1.0912 (rough estimate)
vapor pressure  0Pa at 25℃
refractive index  1.5749 (estimate)
Flash point: >230 °F
storage temp.  2-8°C
solubility  soluble in Methanol
pka 8.99±0.10(Predicted)
form  Crystalline Powder
color  White to light beige
Water Solubility  144.6mg/L at 25℃
CAS DataBase Reference 303-26-4(CAS DataBase Reference)
NIST Chemistry Reference Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-(303-26-4)

Safety information for 1-(4-Chlorobenzhydryl)piperazine

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H315:Skin corrosion/irritation
H317:Sensitisation, Skin
H318:Serious eye damage/eye irritation
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for 1-(4-Chlorobenzhydryl)piperazine

Abamectin manufacturer

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product: 303-26-4 Cetirizine EP Impurity-A 98%
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Lorven therapeutics Pvt Ltd

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product: p-Chlorobenzhydryl Piperazine 98%
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KARUNESH REMEDIES

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