1-(4-Chlorobenzhydryl)piperazine
Synonym(s):(RS)-1-[(4-Chlorophenyl)phenylmethyl]piperazine;1-(4-Chlorobenzhydryl)piperazine;Norchlorcyclizine;NSC 86164
- CAS NO.:303-26-4
- Empirical Formula: C17H19ClN2
- Molecular Weight: 286.8
- MDL number: MFCD00005965
- EINECS: 206-137-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is 1-(4-Chlorobenzhydryl)piperazine?
Chemical properties
White Solid
The Uses of 1-(4-Chlorobenzhydryl)piperazine
A metabolite of Cetirizine (C281100) and Hydroxyzine. Citirizine impurity A.
The Uses of 1-(4-Chlorobenzhydryl)piperazine
Cetrizine Dihydrochloride intermediate
What are the applications of Application
1-[(4-Chlorophenyl)phenylmethyl]piperazine is a metabolite of Cetirizine and Hydroxyzine
Preparation
Preparation of 1-[(4-chlorophenyl)phenylmethyl]piperazine. (CPMP)
About 0.5 mL of DMF, 0.1 g of KI and 10 g (0.12 mol) of piperazine were mixed with 15 mL of toluene and heated to 80oC for 0.5 h. This mixture at 80oC was mixed with 4-CBC in toluene and the temperature was maintained at 80oC for a period of 2 h followed by refluxing at the same temperature for 12h. The reaction mixture was then cooled to 20oC. The toluene layer was washed twice with 20 mL of water and treated with HCl (15 mL conc. HCl in 5mL of water) at 5-10oC. The reaction mixture was filtered and the aqueous layer was separated from the filtrate. About 10 mL of toluene and 10 mL of methylene dichloride (MDC) washes were given to the aqueous layer and neutralized with 22 mL of 30 % NaOH solution at 10oC and maintained at 20oC for 2h. The solid compound formed was filtered, sucked and dried at 50oC for 3 h.Yield: 92 %; m.p: 63-65oC.
Flammability and Explosibility
Not classified
Safety Profile
An experimental teratogen.Experimental reproductive effects. When heated todecomposition it emits very toxic fumes of NOx and Clí.
Properties of 1-(4-Chlorobenzhydryl)piperazine
Melting point: | 65-70 °C (lit.) |
Boiling point: | 178-180 °C/0.5 mmHg (lit.) |
Density | 1.0912 (rough estimate) |
vapor pressure | 0Pa at 25℃ |
refractive index | 1.5749 (estimate) |
Flash point: | >230 °F |
storage temp. | 2-8°C |
solubility | soluble in Methanol |
pka | 8.99±0.10(Predicted) |
form | Crystalline Powder |
color | White to light beige |
Water Solubility | 144.6mg/L at 25℃ |
CAS DataBase Reference | 303-26-4(CAS DataBase Reference) |
NIST Chemistry Reference | Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-(303-26-4) |
Safety information for 1-(4-Chlorobenzhydryl)piperazine
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for 1-(4-Chlorobenzhydryl)piperazine
Abamectin manufacturer
chemmolelaboratories private limited
GLP Pharma Standards
Lorven therapeutics Pvt Ltd
KARUNESH REMEDIES
KARPSCHEM LABORATORIES PVT. LTD.
Varanous Labs Pvt Ltd
CNS CHEMICALS
Chemikos Laboratories Pvt Ltd
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