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HomeProduct name listBromo-tris-pyrrolidino-phosphonium hexafluorophosphate

Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate

Synonym(s):Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate;PyBroP

  • CAS NO.:132705-51-2
  • Empirical Formula: C12H24BrF6N3P2
  • Molecular Weight: 466.19
  • MDL number: MFCD00077412
  • EINECS: 620-834-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate Structural

What is Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate?

Chemical properties

white to off-white powder

The Uses of Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate

A stable reagent for the coupling of N-Methylamino acids in peptide synthesis.

The Uses of Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate

It can be used as a coupling reagent:

  • For Suzuki–Miyaura cross-coupling of phenols and arylboronic acids to synthesize biaryls and heterobiaryls.
  • To functionalize pyrimidines (synthesized from 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via the Kappe dehydrogenation) by using various nucleophiles.
  • To synthesize formamidines by coupling with various primary amines and N,N-diisopropylethylamine.

It can also be used as an activating reagent:
  • For the activation of C-OH bond in tautomerizable heterocycles to form the phosphonium salt which aids the Sonogashira coupling of heterocycles with various alkynes.
  • For the one–pot activation of C-O bond in phenols and further coupling reaction with phosphine oxide or phosphite to form C-P bonds.

Properties of Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate

Melting point: 100 °C
storage temp.  -20°C
solubility  DMF: 0.4 g/mL, clear
form  Powder
color  White to off-white
Water Solubility  moderately soluble
Sensitive  Moisture Sensitive
BRN  7845702
Stability: Moisture Sensitive
CAS DataBase Reference 132705-51-2(CAS DataBase Reference)

Safety information for Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H314:Skin corrosion/irritation
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P363:Wash contaminated clothing before reuse.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate

InChIKey CYKRMWNZYOIJCH-UHFFFAOYSA-N

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