Bromhexine hydrochloride

Description

Bromhexine Hydrochloride is the hydrochloride salt of bromhexine, which possesses secretolytic and mucolytic properties. It works by increasing lysosomal activity within the respiratory tract, which in turn enhances the hydrolysis of acid mucopolysaccharide polymers. This process results in the production of serous mucus, leading to a reduction in the viscosity of the phlegm and making it thinner.

Chemical properties

White Solid

Originator

Bisolvon,Boehringer Ingelheim,Switz.,1963

The Uses of Bromhexine hydrochloride

Bromhexine hydrochloride is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.
Bromhexine hydrochloride belongs to the group of expectorants (mucoactive agents). The active substance has a secretolytic effect. It is used for the treatment of strong cough, e.g. triggered by a bronchitis.

The Uses of Bromhexine hydrochloride

Bromhexine hydrochloride was used in the secretion of pancreatic juice of low viscosity.

What are the applications of Application

Bromhexine Hydrochloride functions as both a secretagogic and a mucolytic agent.

Definition

ChEBI: A hydrochloride resulting from the reaction of equimolar amounts of bromhexine and hydrogen chloride. It is used as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of spu um).

Manufacturing Process

In initial steps, 2-nitrobenzylbromide and cyclohexylmethylamine are reacted and that initial product reacted with hydrazine to give N-(2-aminobenzyl)-Nmethyl- cyclohexylamine.
A solution of 29.3 g of bromine in 50 cc of glacial acetic acid was slowly added dropwise to a solution of 159 g of N-(2-aminobenzyl)-N-methylcyclohexylamine, accompanied by stirring. The glacial acetic acid was decanted from the precipitate formed during the addition of the bromine solution, and the precipitate was thereafter shaken with 200 cc of 2N sodium hydroxide and 600cc of chloroform until all of the solids went into solution. The chloroform phase was allowed to separate from the aqueous phase. The chloroform phase was decanted, evaporated to dryness and the residue was dissolved in absolute ether. The resulting solution was found to be a solution of N-(2-amino-3,5-dibromobenzyl)-N-methyl-cyclohexylamine in ethanol. Upon introducing hydrogen chloride into this solution, the hydrochloride of N-(2- amino-3,5-dibromobenzyl)-N-methyl-cyclohexylamine precipitated out. It had a melting point of 232°-235°C (decomposition).

Therapeutic Function

Expectorant; Mucolytic

General Description

Bromhexine hydrochloride is a bronchial mucolytic.