Valganciclovir hydrochloride
Synonym(s):L -Valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester monohydrochloride;2-[(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]-3-hydroxypropyl (2S)-2-amino-3-methylbutanoate hydrochloride hydrate;L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, monohydrochloride hydrate;Valganciclovir hydrochloride hydrate
- CAS NO.:175865-59-5
- Empirical Formula: C14H23ClN6O5
- Molecular Weight: 390.82
- MDL number: MFCD08460118
- EINECS: 641-360-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-12 23:00:59
What is Valganciclovir hydrochloride?
Description
Valganciclovir hydrochloride, a prodrug of the antiviral ganciclovir, was launched in the US for the oral treatment of cytemegalovirus (CMV) retinitis, a sight-threatening complication in patients with AIDS. This L-Valyl ester prodrug can be prepared in three steps from the nucleoside analog ganciclovir by trimethylsilyl-protection of the amino group, coupling with N-benzyloxycarbonyl-L-valine-N-carboxyanhydride, hydrolysis with hydrochloric acid and hydrogenolysis of the Cbz-protecting group. Valganciclovir is well absorbed and rapidly hydrolyzed to ganciclovir by intracellular esterases in the intestinal mucosal cells and by hepatic esterases. Unlike ganciclovir, valganciclovir was demonstrated to be actively transported by the intestinal peptide transporter PEPT1 in Caco-2 cells. As a consequence, its absolute bioavailability in human was 10-fold higher compared to ganciclovir (6%). In clinical trials, it was shown that a twice-daily 900 mg dose of valganciclovir resulted in similar systemic ganciclovir exposure to 5 mg/kg twice-daily intravenous injection of ganciclovir. Valganciclovir concentrations could not be quantified in most patients within three to four hours. In a randomized non-blind phase III clinical trial, oral valganciclovir (900 mg twice daily for three weeks then 900 mg once daily for one week) was as effective as intravenous ganciclovir (5 mg/kg twice daily for three weeks then 5 mg/kg once daily). Oral treatment with valganciclovir avoided catheter-related infection that sometimes occurred with intravenous ganciclovir.
The Uses of Valganciclovir hydrochloride
Valganciclovir hydrochloride hydrate may be used in HIV-related cell signaling studies.
What are the applications of Application
Valganciclovir Hydrochloride is a pro-drug of ganciclovir
Properties of Valganciclovir hydrochloride
Melting point: | 162-164°C |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | H2O: ≥8mg/mL |
form | powder |
color | white to tan |
Safety information for Valganciclovir hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H332:Acute toxicity,inhalation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P330:Rinse mouth. P363:Wash contaminated clothing before reuse. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P501:Dispose of contents/container to..… |
Computed Descriptors for Valganciclovir hydrochloride
InChIKey | ZORWARFPXPVJLW-MTFPJWTKSA-N |
Abamectin manufacturer
Sonia Organics
KARPSCHEM LABORATORIES PVT. LTD.
Sun Pharmaceutical Industries Ltd
HRV Global Life Sciences
Arene Lifesciences Limited
BDR Pharmaceuticals International Pvt Ltd
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