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HomeProduct name listBitertanol

Bitertanol

Synonym(s):3,3-Dimethyl-1-(4-phenylphenoxy)-1-(1,2,4-triazol-1-yl)butan-2-ol

  • CAS NO.:55179-31-2
  • Empirical Formula: C20H23N3O2
  • Molecular Weight: 337.42
  • MDL number: MFCD00055508
  • EINECS: 259-513-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Bitertanol Structural

What is Bitertanol?

Description

Bitertanol is a broad-spectrum triazole fungicide that is active against a variety of fungi, including V. inaequalis and V. pirina, which are responsible for apple and pear scab, respectively, as well as S. mors-uvae and P. ribis, which are responsible for American gooseberry mildew and leaf spot in black currants, respectively. It is active against isolates of V. inaequalis (MICs = 0.6 and 1 μg/ml) but repeated use leads to resistance and cross-resistance (MICs = 9.8-13 μg/ml for bitertanol-resistant isolates). Bitertanol inhibits the cytochrome P450 (CYP450) isoform CYP3A4 (IC50 = 2.74 μM) and inhibits androgenic activity induced by the androgen receptor agonist DHT in a yeast two-hybrid assay (IC50 = 79.85 μM). In rats, bitertanol (10-300 mg/kg, i.p.) increases operant responding on one- and five-minute fixed interval schedules with no effect on motor activity.

Chemical properties

White Solid

The Uses of Bitertanol

Bitertanol is a foliar-applied triazole fungicide used to protect tropical and subtropical crops in agriculture, in particular bananas. Bitertanol has effects on behavior that are similar to those of psychomotor stimulants.

The Uses of Bitertanol

Agricultural fungicide.

The Uses of Bitertanol

Bitertanol is used as a seed treatment on winter wheat and barley and as a foliar treatment to control diseases on bananas, ornamentals, fruit and vegetables.

What are the applications of Application

Bitertanol is a triazole fungicide used to kill tropical and subtropical fungi in vitro

Definition

ChEBI: 1-(biphenyl-4-yloxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-ol is a member of the class of triazoles that is 3,3-dimethyl-1-(1,2,4-triazol-1-yl)butane-1,2-diol substituted at position O-1 by a biphenyl-4-yl group. It is a member of biphenyls, an aromatic ether, a member of triazoles and a secondary alcohol.

Agricultural Uses

Fungicide: A fungicide used to control a variety of diseases. Used as control for prunes when drying. Not currently registered in the U.S. or EU countries (pending). Used in many European, South American, Far Eastern and African countries, a well as in Australia for use on beans (all types) and various ornamentals. More than 20 global suppliers.

Trade name

BAYCOR®; BAY KWG 0599®; BAYMATSPRAY ®; BILOXAZOL®; KWG 0599®; SIBUTOL®, (with Fuberidazole)

Metabolic pathway

Bitertanol is a mixture of two diastereoisomeric pairs and this complicates its metabolism, each biotransfonnation affording a mixture of isomers. Metabolism has been studied under environmental conditions and in plants and mammals. Degradation in soil and sediments is slow and only small quantities of products (other than CO2 and bound residues) are produced. Most information is available for mammals in which metabolism occurs mainly by oxidative routes followed by conjugation. The information presented below is derived from the UK MAFF Pesticide Safety Directorate (PSD, 1994).

Degradation

The hydrolytic stability of [14C]bitertanowl as measured at pH 4, 7 and 9 over 30 days at 25 and 40 °C. No decomposition was observed and the DT50 was estimated at >1 year at 25 °C.
Aqueous solutions of [14C-triazole]-and [14C-biphenyl]-bitertanol were irradiated for 48 and 72 hours, respectively, using a mercury arc lamp under conditions somewhat exceeding natural sunlight. Calculated DT50 values were 38-52 hours and an estimated environmental DT50 was considered to be 11 days. 4-Hydroxybiphenyl (4) and 1,2,4-triazole (5) were identified as major photolysis products accounting for 12% and 53% of the radioactivity, respectively. These are shown in Scheme 1. At least six minor products were detected but these were not identified.
Very little degradation occurred under soil surface photolysis conditions simulating natural sunlight. No discrete products were detected. Bound residue increased to only 5% of the total over 35 days.

Properties of Bitertanol

Melting point: 49-50°C
Boiling point: 350°C
Density  1.1676 (rough estimate)
vapor pressure  A 2.2 x l0-10 (20 °C) B 2.5 x l0-9 (20 °C)
refractive index  1.6200 (estimate)
Flash point: 100 °C
solubility  Chloroform: slightl soluble,DMSO: Slightly Soluble,Methanol: Slightly Soluble
form  neat
Water Solubility  A 2.7 mg l-1 (20 °C) B 1.1 mg l-1 (20 °C)
pka 13.40±0.20(Predicted)
Merck  13,1301
BRN  620948
NIST Chemistry Reference 1H-1,2,4-triazole-1-ethanol, «beta»-([1,1'-biphenyl]-4-yloxy)-«alpha»-(1,1-dimethylethyl)-(55179-31-2)
EPA Substance Registry System Bitertanol (55179-31-2)

Safety information for Bitertanol

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for Bitertanol

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