Bisindolylmaleimide V

Synonym(s):2,3- bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045;2,3-bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045;Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem

CAS NO.：113963-68-1
Empirical Formula: C21H15N3O2
Molecular Weight: 341.36
MDL number: MFCD00236433
EINECS: 604-604-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is Bisindolylmaleimide V?

Description

Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1?Does not inhibit PKC (at concentrations <100?mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2?such as GF 109203X3?and other structurally related inhibitors4.

What are the applications of Application

Bisindolylmaleimide V is a negative control for protein kinase C (PKC)-inhibitory activity

Definition

ChEBI: Ro 31-6045 is a member of indoles.

References

1) Marmy-Conus?et al.?(2002),?Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling; FEBS Lett.,?519?135 2) Harmon?et al.?(1997),?Bisindolylmaleimide protein-kinase C inhibitors delay in the decline in DNA synthesis in mouse hair follicle organ cultures; Skin Pharmacol.,?10?71 3) Toullec?et al.?(1991),?The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol. Chem.,?266?15771 4) Davis?et al. (1992),?Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides; J. Med. Chem.,?35?177

Properties of Bisindolylmaleimide V

Melting point:	>260 °C
Boiling point:	655.7±55.0 °C(Predicted)
Density	1.450±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: soluble
form	solid
pka	15.89±0.30(Predicted)
color	Orange
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference	113963-68-1(CAS DataBase Reference)

Safety information for Bisindolylmaleimide V

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.