Bis-Tris propane
Synonym(s):1,3-Bis[tris(hydroxymethyl)methylamino]propane
- CAS NO.:64431-96-5
- Empirical Formula: C11H26N2O6
- Molecular Weight: 282.33
- MDL number: MFCD00004689
- EINECS: 264-899-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-13 17:19:14
What is Bis-Tris propane?
Description
BIS-TRIS Propane is Good′s buffer. It acts as ligand and forms series of dinuclear hydroxo complexes with Lanthanides(III) in the pH range 7-9. It is useful for diagnostic assay manufacturing industry.
Chemical properties
White powder
The Uses of Bis-Tris propane
BIS-Tris Propane is a buffer that is useful in the pH 6.3 - 9.5 range. This wide buffering range is due to its two pKa values, 6.8 (pKa1) and 9.0 (pKa2), being so close. Because of the wide buffering range, particularly down to pH 6 - 7, this buffer has been used to enhance the stability or activity of restriction enzymes, compared to Tris buffer (which is a poor buffer below pH 7.5 and has a comparatively large change in pKa with temperature).
The Uses of Bis-Tris propane
BIS-TRIS Propane may be used in the following studies:
- As buffer to investigate the influence of anions with varying nucleophilic properties on the autoxidation of oxymyoglobin (MbO2).
- Purification of glucose-binding protein from membranes of Sulfolobus solfataricus.
- As buffer during GeO2 mineralisation.
What are the applications of Application
BIS-Tris Propane is a buffer that is useful in the pH 6.3-9.5 range
Definition
ChEBI: Bis-tris propane is a water-soluble buffer substance used for the preparation of the biochemical and biological buffer solutions; pKa = 6.8 at 20 ℃. It has a role as a buffer. It is functionally related to a member of tris.
Precautions
This trihydroxyamine analog, also known as bis-tris propane, presents as a white to almost white crystalline powder. Store in a cool and dark place. 1,3-Bis[tris(hydroxymethyl)methylamino]propane is known to be incompatible with oxidizing agents and should not be handled in their vicinity.
Properties of Bis-Tris propane
Melting point: | 164-165 °C(lit.) |
Boiling point: | 573.3±50.0 °C(Predicted) |
Density | 1.326±0.06 g/cm3(Predicted) |
storage temp. | room temp |
solubility | H2O: 1 M at 20 °C, clear, colorless |
form | Powder/Solid |
color | White |
PH | 9.0-10.1 (20-25℃, 1M in water) |
pka | (1) 6.8, (2) 9.0(at 25℃) |
PH Range | 6.3 - 9.5 |
Water Solubility | Soluble in water. |
BRN | 1786109 |
InChI | InChI=1S/C11H26N2O6/c14-4-10(5-15,6-16)12-2-1-3-13-11(7-17,8-18)9-19/h12-19H,1-9H2 |
CAS DataBase Reference | 64431-96-5(CAS DataBase Reference) |
Safety information for Bis-Tris propane
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Bis-Tris propane
InChIKey | HHKZCCWKTZRCCL-UHFFFAOYSA-N |
SMILES | C(NC(CO)(CO)CO)CCNC(CO)(CO)CO |
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