BIOTINAMIDOCAPROYL HYDRAZIDE
Synonym(s):(+)-Biotin-ε-aminocaproyl hydrazide;(+)-Biotinamidocaproyl hydrazide;(+)-Biotin-X-hydrazide;BACH;N-(+)-Biotinyl-6-aminohexanoic hydrazide
- CAS NO.：109276-34-8
- Empirical Formula: C16H29N5O3S
- Molecular Weight: 371.5
- MDL number: MFCD00077659
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is BIOTINAMIDOCAPROYL HYDRAZIDE?
Description
This is a hydrazide-activated biotinylation reagent used to label glycoproteins, carbohydrate-containing compounds that have oxidizable sugars or aldehydes. Hydrazine moiety reacts with an aldehyde to form semi-permanent hydrazone bonds. The extended spacer arm helps to minimize steric hindrance.
Chemical properties
mp 195°C
The Uses of BIOTINAMIDOCAPROYL HYDRAZIDE
Biotinylation reagent with aminocaproic spacer for aldehyde groups (e.g., periodate-oxidized sugars) and carboxylic acids. Typically used for coupling to glycoproteins through the carbohydrate by hydrazone bond formation.
What are the applications of Application
Biotin LC hydrazide is carbohydrate reactive with a spacer arm and is more sensitive than biotin hydrazide
Purification Methods
Suspend the hydrazide in ice-water (100mg/mL), stand overnight at 4o, filter and dry the solid in a vacuum. Recrystallise it from isoPrOH. RF is 0.26 on SiO2 plate using CHCl3/MeOH (7:3) as eluent. [O'Shannessy et al. Anal Biochem 163 204 1987.]
Properties of BIOTINAMIDOCAPROYL HYDRAZIDE
| Melting point: | 195-196°C |
| Boiling point: | 777.0±55.0 °C(Predicted) |
| Density | 1.188±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 25 mg/mL |
| form | powder |
| pka | 13.26±0.35(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 109276-34-8(CAS DataBase Reference) |
Safety information for BIOTINAMIDOCAPROYL HYDRAZIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P362:Take off contaminated clothing and wash before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for BIOTINAMIDOCAPROYL HYDRAZIDE
| InChIKey | IJJWOSAXNHWBPR-HUBLWGQQSA-N |
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