BIOTIN DISULFIDE N-HYDROXY-SUCCINIMIDE ESTER
Synonym(s):(2-[Biotinamido]ethylamido)-3,3′-dithiodipropionic acid N-hydroxysuccinimide ester
- CAS NO.:142439-92-7
- Empirical Formula: C22H33N5O7S3
- Molecular Weight: 575.72
- MDL number: MFCD00466919
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-21 17:31:59
What is BIOTIN DISULFIDE N-HYDROXY-SUCCINIMIDE ESTER?
Description
Biotin-bisamido-SS-NHS is a cleavable reagent which can efficiently introduce a biotin moiety to amine-containing biomolecules. The cross-bridge and extended spacer arm are helpful in minimizing steric hindrance involved with the binding to avidin or streptavidin probes. This biotin compound is membrane-permeable and useful for intracellular labeling. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label.
The Uses of BIOTIN DISULFIDE N-HYDROXY-SUCCINIMIDE ESTER
NHS SS Biotin is a amine reactive biotinylation reagent that labels antibodies and other proteins and molecules that contain primary amines. NHS SS Biotin reacts efficiently with pirmary amino groups in alkaline buffers to form stable amide bonds. The disulfide bond in the spacer arm of NHS SS Biotin is also cleavable using reducing agents such as TCEP and DTT.
The Uses of BIOTIN DISULFIDE N-HYDROXY-SUCCINIMIDE ESTER
NHS SS Biotin is a amine reactive biotinylation reagent that labels antibodies and other proteins and molecules that contain primary amines. NHS SS Biotin reacts efficiently with pirmary amino groups in alkaline buffers to form stable amide bonds. The disulfide bond in the spacer arm of NHS SS Biotin is also cleavable using reducing agents such as TCEP and DTT.
Properties of BIOTIN DISULFIDE N-HYDROXY-SUCCINIMIDE ESTER
Melting point: | 129-131°C |
Density | 1.43 |
storage temp. | −20°C |
solubility | DMF: 50 mg/mL |
form | powder |
pka | 13.90±0.40(Predicted) |
Safety information for BIOTIN DISULFIDE N-HYDROXY-SUCCINIMIDE ESTER
Signal word | Danger |
Pictogram(s) |
Health Hazard GHS08 |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for BIOTIN DISULFIDE N-HYDROXY-SUCCINIMIDE ESTER
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