Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listBIOTIN HYDRAZIDE

BIOTIN HYDRAZIDE

  • CAS NO.:66640-86-6
  • Empirical Formula: C10H18N4O2S
  • Molecular Weight: 258.34
  • MDL number: MFCD00078532
  • EINECS: 613-970-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
BIOTIN HYDRAZIDE Structural

What is BIOTIN HYDRAZIDE?

Description

Biotin hydrazide is a biotinyl derivative used to label surface functional groups, antibodies, lectins, sugars, nucleic acids, or molecules with free carboxylic or keto groups. Biotin hydrazide is used as a probe for determining protein carbonylation, an irreversible posttranslational modification resulting from the actions of reactive oxygen species or lipid oxidation products. The reaction of this probe is direct and does not require catalysts or reducing agents.

Chemical properties

3.6

The Uses of BIOTIN HYDRAZIDE

Biotin Hydrazide is a carbohydrate reactive biotinylation reagent used predominately for labeling monoclonal antibodies, unpaired cytosine residues in nucleic acids and glycoproteins.

The Uses of BIOTIN HYDRAZIDE

aldehyde reactive biotinylation reagent

The Uses of BIOTIN HYDRAZIDE

(+)-Biotin hydrazide has been used:

  • the modification of alginate
  • for the labelling of mitochondrial proteins from non-muscle tissues
  • as a component of glycoprotein staining solution
  • in periodic acid-biotin-hydrazide (PABH) assay for mucins
  • for labeling surface functional groups, biologically active molecules such as antibodies, lectins, sugars, nucleic acids or molecules with free carboxylic or keto groups.
  • for coupling to glycoproteins through the carbohydrate by hydrazone formation

What are the applications of Application

(+)-Biotin hydrazide is a functionalized derivative that allows biotinylation of glycoproteins and glycolipids

General Description

Biotin hydrazide is a biotinylation reagent used to biotinylate glycoproteins with their sugar moieties. Biotin hydrazide can be used to prepare biotin-conjugated alginate. It can also be used for covalent attachment to PAAc via carbodi-imide cross linking.

Purification Methods

Wash the hydrazide with H2O, dry it, wash it with MeOH then Et2O, and dry. Recrystallise it from hot H2O (clusters of prisms) [Hofmann et al. J Biol Chem 144 513 1942]. [Beilstein 27 III/IV 7980.]

Properties of BIOTIN HYDRAZIDE

Melting point: 245-247 °C
Boiling point: 633.1±40.0 °C(Predicted)
Density  1.243±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: ≤20 mg/mL
form  powder
pka 13.25±0.35(Predicted)
color  White to Almost white
BRN  28347
CAS DataBase Reference 66640-86-6(CAS DataBase Reference)

Safety information for BIOTIN HYDRAZIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for BIOTIN HYDRAZIDE

InChIKey KOZWHQPRAOJMBN-ZKWXMUAHSA-N

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.