BETAMETHASONE BENZOATE (200 MG)
Synonym(s):Betamethasone 17-benzoate
- CAS NO.:22298-29-9
- Empirical Formula: C35H41FO8
- Molecular Weight: 608.6936432
- MDL number: MFCD00867437
- EINECS: 2448979
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-21 10:59:17
What is BETAMETHASONE BENZOATE (200 MG)?
Originator
Benisone,Warner Lambert,US,1973
The Uses of BETAMETHASONE BENZOATE (200 MG)
BETAMETHASONE BENZOATE (200 MG) is an analog of Betamethasone (B327000), a glucocorticoid used as an anti-inflammatory agent.
Definition
ChEBI: Betamethasone benzoate is a 21-hydroxy steroid.
Manufacturing Process
A mixture of 50 g of betamethasone, 50 cc of dimethylformamide, 50 cc of methyl orthobenzoate and 1.5 g of p-toluenesulfonic acid is heated for 24 hours on oil bath at 105°C while a slow stream of nitrogen is passed through the mixture and the methanol produced as a byproduct of the reaction is distilled off. After addition of 2 cc of pyridine to neutralize the acid catalyst the solvent and the excess of methyl orthobenzoate are almost completely eliminated under vacuum at moderate temperature. The residue is chromatographed on a column of 1,500 g of neutral aluminum oxide. By elution with ether-petroleum ether 30 g of a crystalline mixture are obtained consisting of the epimeric mixture of 17α,21-methyl orthobenzoates. This mixture is dissolved without further purification, in 600 cc of methanol and 240 cc of methanol and 240 cc of aqueous 2N oxalic acid are added to the solution. The reaction mixture is heated at 40°-50°C on water bath, then concentrated under vacuum, The residue, crystallized from acetone-ether, gives betamethasone 17-benzoate, MP 225°-231°C.
brand name
Uticort (Parke- Davis).
Therapeutic Function
Glucocorticoid
Safety Profile
Poison by subcutaneous route.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits toxic fumes of F-.
Properties of BETAMETHASONE BENZOATE (200 MG)
Melting point: | 225-228° |
Boiling point: | 641.0±55.0 °C(Predicted) |
alpha | D24 +63.5° (dioxane) |
Density | 1.1732 (estimate) |
storage temp. | Store at -20°C |
solubility | Soluble in DMSO |
pka | 12.93±0.70(Predicted) |
Safety information for BETAMETHASONE BENZOATE (200 MG)
Signal word | Danger |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H373:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for BETAMETHASONE BENZOATE (200 MG)
Abamectin manufacturer
Varanous Labs Pvt Ltd
Allmpus Laboratories Pvt Ltd
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