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HomeProduct name listBETAMETHASONE BENZOATE (200 MG)

BETAMETHASONE BENZOATE (200 MG)

Synonym(s):Betamethasone 17-benzoate

  • CAS NO.:22298-29-9
  • Empirical Formula: C35H41FO8
  • Molecular Weight: 608.6936432
  • MDL number: MFCD00867437
  • EINECS: 2448979
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-21 10:59:17
BETAMETHASONE BENZOATE (200 MG) Structural

What is BETAMETHASONE BENZOATE (200 MG)?

Originator

Benisone,Warner Lambert,US,1973

The Uses of BETAMETHASONE BENZOATE (200 MG)

BETAMETHASONE BENZOATE (200 MG) is an analog of Betamethasone (B327000), a glucocorticoid used as an anti-inflammatory agent.

Definition

ChEBI: Betamethasone benzoate is a 21-hydroxy steroid.

Manufacturing Process

A mixture of 50 g of betamethasone, 50 cc of dimethylformamide, 50 cc of methyl orthobenzoate and 1.5 g of p-toluenesulfonic acid is heated for 24 hours on oil bath at 105°C while a slow stream of nitrogen is passed through the mixture and the methanol produced as a byproduct of the reaction is distilled off. After addition of 2 cc of pyridine to neutralize the acid catalyst the solvent and the excess of methyl orthobenzoate are almost completely eliminated under vacuum at moderate temperature. The residue is chromatographed on a column of 1,500 g of neutral aluminum oxide. By elution with ether-petroleum ether 30 g of a crystalline mixture are obtained consisting of the epimeric mixture of 17α,21-methyl orthobenzoates. This mixture is dissolved without further purification, in 600 cc of methanol and 240 cc of methanol and 240 cc of aqueous 2N oxalic acid are added to the solution. The reaction mixture is heated at 40°-50°C on water bath, then concentrated under vacuum, The residue, crystallized from acetone-ether, gives betamethasone 17-benzoate, MP 225°-231°C.

brand name

Uticort (Parke- Davis).

Therapeutic Function

Glucocorticoid

Safety Profile

Poison by subcutaneous route.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits toxic fumes of F-.

Properties of BETAMETHASONE BENZOATE (200 MG)

Melting point: 225-228°
Boiling point: 641.0±55.0 °C(Predicted)
alpha  D24 +63.5° (dioxane)
Density  1.1732 (estimate)
storage temp.  Store at -20°C
solubility  Soluble in DMSO
pka 12.93±0.70(Predicted)

Safety information for BETAMETHASONE BENZOATE (200 MG)

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H373:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for BETAMETHASONE BENZOATE (200 MG)

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