Benzylparaben

Synonym(s):4-Hydroxybenzoic acid benzyl ester;Benzyl paraben

CAS NO.：94-18-8
Empirical Formula: C14H12O3
Molecular Weight: 228.24
MDL number: MFCD00016471
EINECS: 202-311-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:07:02

What is Benzylparaben?

Chemical properties

white to light yellow fine powder

The Uses of Benzylparaben

An antimicrobial

The Uses of Benzylparaben

preservative in cosmetics and pharmaceutical preparations

The Uses of Benzylparaben

Benzyl 4-hydroxybenzoate may be used as internal standard for the simultaneous analysis of non-steroidal anti-inflammatory drugs in human plasma and urine using microextraction by packed sorbent and HPLC method. It may be employed as internal standard for the HPLC determination of rutin, kaempferol, genistein, formononetin and biochanin A in Ononis spinosu roots.

Indications

Benzylparaben is used in allergenic testing.

Background

Benzylparaben is used in allergenic testing.

What are the applications of Application

Benzyl Paraben is An anti-microbial agent often used in cosmetic products

Definition

ChEBI: Benzyl parahydroxybenzoate is a benzoate ester and a benzyl ester.

General Description

Benzyl 4-hydroxybenzoate (Paraben, Benzyl Paraben) is an ester of para-hydroxy benzoic acid. It has been added to various cosmetics and personal care products as a preservative. Its quantification in cosmetics has been reported by HPLC methods. Microwave assisted synthesis of benzyl 4-hydroxybenzoate by reaction between (4-hydroxybenzoic) acid and K₂CO₃ in presence of phase transfer catalyst has been reported. It is an endocrine disrupting chemical (EDC). It is a promising candidate for use in pharmaceutical and personal care products. Its visible-light assisted photosensitized degradation in homogeneous aqueous solution of 4,4′,4′′,4′′′-(porphine-5,10,15,20-tetrayl)tetrakis(benzenesulphonic acid) has been investigated.

Flammability and Explosibility

Not classified

Contact allergens

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

Metabolism

Not Available

Properties of Benzylparaben

Melting point:	109-112 °C(lit.)
Boiling point:	170℃
Density	1.1799
vapor pressure	0Pa at 25℃
refractive index	1.5805
Flash point:	167℃
storage temp.	Inert atmosphere,2-8°C
solubility	ethanol: soluble25mg/mL, clear, colorless
form	Powder
pka	8.18±0.15(Predicted)
color	White to Almost white
Water Solubility	92mg/L(25 ºC)
BRN	2115995
CAS DataBase Reference	94-18-8(CAS DataBase Reference)
NIST Chemistry Reference	Benzyl 4-hydroxybenzoate(94-18-8)
EPA Substance Registry System	Benzoic acid, 4-hydroxy-, phenylmethyl ester (94-18-8)

Safety information for Benzylparaben

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.