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HomeProduct name listBenidipine

Benidipine

  • CAS NO.:105979-17-7
  • Empirical Formula: C28H31N3O6
  • Molecular Weight: 505.56
  • MDL number: MFCD00906929
  • EINECS: 857-680-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
Benidipine Structural

What is Benidipine?

The Uses of Benidipine

Benidipine (CAS# 105979-17-7) is a 1,4-dihydropyridine and a calcium channel antagonist. Antihypertensive.

What are the applications of Application

Benidipine is a dihydropyridine calcium channel blocker

Enzyme inhibitor

This oral, once-daily antihypertensive agent (FW = 505.57 g/mol; CAS 105979-17-7), also known by its code name KW-3049, trade name Coniel?, and systematic name O -methyl,O -[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, is a dihydropyridine-class calcium ion blocker that is effective against L-, N-, and T-channels, with potent and selective inhibitory action on cardiac slow calcium channels. Benidipine bound stereospecifically to nitrendipine binding sites of rat myocardium with high affinity (Ki = 0.13 nM) and to the rat brain a1-adrenergic receptor (Ki = 1.2 μM). KW-3049 exhibited no remarkable binding affinity to a2 adrenergic, b-adrenergic, D2 dopamine, H1 histamine, S2 serotonin, A1 adenosine, A2 adenosine and muscarinic cholinergic receptors at 100 μM.

Properties of Benidipine

Boiling point: 625.2±55.0 °C(Predicted)
Density  1.29±0.1 g/cm3(Predicted)
pka pKa 7.34(H2O(long extrapolation) ) (Uncertain)
Water Solubility  316μg/L at 25℃
CAS DataBase Reference 105979-17-7(CAS DataBase Reference)

Safety information for Benidipine

Computed Descriptors for Benidipine

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