Benidipine
- CAS NO.:105979-17-7
- Empirical Formula: C28H31N3O6
- Molecular Weight: 505.56
- MDL number: MFCD00906929
- EINECS: 857-680-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 15:12:06
What is Benidipine?
The Uses of Benidipine
Benidipine (CAS# 105979-17-7) is a 1,4-dihydropyridine and a calcium channel antagonist. Antihypertensive.
What are the applications of Application
Benidipine is a dihydropyridine calcium channel blocker
Enzyme inhibitor
This oral, once-daily antihypertensive agent (FW = 505.57 g/mol; CAS 105979-17-7), also known by its code name KW-3049, trade name Coniel?, and systematic name O -methyl,O -[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, is a dihydropyridine-class calcium ion blocker that is effective against L-, N-, and T-channels, with potent and selective inhibitory action on cardiac slow calcium channels. Benidipine bound stereospecifically to nitrendipine binding sites of rat myocardium with high affinity (Ki = 0.13 nM) and to the rat brain a1-adrenergic receptor (Ki = 1.2 μM). KW-3049 exhibited no remarkable binding affinity to a2 adrenergic, b-adrenergic, D2 dopamine, H1 histamine, S2 serotonin, A1 adenosine, A2 adenosine and muscarinic cholinergic receptors at 100 μM.
Properties of Benidipine
Boiling point: | 625.2±55.0 °C(Predicted) |
Density | 1.29±0.1 g/cm3(Predicted) |
pka | pKa 7.34(H2O(long extrapolation)
) (Uncertain) |
Water Solubility | 316μg/L at 25℃ |
CAS DataBase Reference | 105979-17-7(CAS DataBase Reference) |
Safety information for Benidipine
Computed Descriptors for Benidipine
Abamectin manufacturer
Dayaram Pharma Chem
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