Basic Orange 14
Synonym(s):3,6-Bis(dimethylamino)acridine hydrochloride zinc chloride double salt;3,6-Bis(dimethylamino)acridinium chloride hemi(zinc chloride salt);Acridine orange zinc chloride double salt (C.I.46005);Basic Orange 14
- CAS NO.:10127-02-3
- Empirical Formula: C17H20Cl3N3Zn
- Molecular Weight: 438.1
- MDL number: MFCD00081043
- EINECS: 233-353-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is Basic Orange 14?
Chemical properties
brown powder
The Uses of Basic Orange 14
Fluorescent stain for nucleic acids. An RNA polymerase inhibitorAcridine Orange acts as a lysosomal dye. It is used for cell-cycle studies. It plays an important role as a nucleic acid-selective fluorescent cationic dye, which is useful for cell cycle determination. Further, it serves as an inhibitor of RNA polymerase.
The Uses of Basic Orange 14
Acridine Orange, a cell-permeable metachromatic fluorescent cationic dye that intercalates DNA and RNA, is used in fluorescence and epiflouresence microscopy. Acridine Orange dye has been used to analyze mitochondria and lysosomal content by flow cytometry, characterize multidrug resistance, and measure changes in mitochondrial mass during apoptosis in rat thymocytes.
What are the applications of Application
Acridine Orange hemi(zinc chloride) salt is fluorescent dye that stains DNA and RNA
General Description
Acridine orange is a metachromatic fluorescent cationic dye that permeates the cell membrane and intercalates DNA and RNA. It allows for visual detection of nucleic acids on agarose and polyacrylamide gels.
Biochem/physiol Actions
Acridine orange (AO) is a fluorescent dye with two different staining characteristics. In fixed tissues, it acts as a metachromatic dye and differentially stains DNA (green) and RNA (orange). But, in living cells it acts as a pH indicator and produce brilliant orange-red in acidic condition. AO has been used to identify apoptotic cells in drosophila embryos. Acridine Orange staining method has been used to deliver more consistent data in the micronucleus test.
Properties of Basic Orange 14
Melting point: | 165 °C |
storage temp. | room temp |
solubility | H2O: soluble1mg/mL, clear, orange to very deep orange |
form | Solid |
Colour Index | 46005 |
pka | pKa -3.3(H2O T=room temperature(RT) Iunspeci?ed) (Uncertain);0.2(H2O T=room temperature(RT) Iunspeci?ed) (Uncertain);10.1(H2O T=room temperature(RT) Iunspeci?ed) (Uncertain) |
color | Red brown |
PH | 3.9 (10g/l, H2O, 20℃) |
Water Solubility | soluble |
Sensitive | Hygroscopic |
BRN | 3734978 |
Stability: | Stable. Incompatible with strong oxidizing agents. Protect from moisture. Hygroscopic. |
CAS DataBase Reference | 10127-02-3(CAS DataBase Reference) |
Safety information for Basic Orange 14
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H341:Germ cell mutagenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Basic Orange 14
Abamectin manufacturer
Pallav Chemicals And Solvents Pvt Ltd
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