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HomeProduct name listBasic Orange 14

Basic Orange 14

Synonym(s):3,6-Bis(dimethylamino)acridine hydrochloride zinc chloride double salt;3,6-Bis(dimethylamino)acridinium chloride hemi(zinc chloride salt);Acridine orange zinc chloride double salt (C.I.46005);Basic Orange 14

  • CAS NO.:10127-02-3
  • Empirical Formula: C17H20Cl3N3Zn
  • Molecular Weight: 438.1
  • MDL number: MFCD00081043
  • EINECS: 233-353-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
Basic Orange 14 Structural

What is Basic Orange 14?

Chemical properties

brown powder

The Uses of Basic Orange 14

Fluorescent stain for nucleic acids. An RNA polymerase inhibitorAcridine Orange acts as a lysosomal dye. It is used for cell-cycle studies. It plays an important role as a nucleic acid-selective fluorescent cationic dye, which is useful for cell cycle determination. Further, it serves as an inhibitor of RNA polymerase.

The Uses of Basic Orange 14

Acridine Orange, a cell-permeable metachromatic fluorescent cationic dye that intercalates DNA and RNA, is used in fluorescence and epiflouresence microscopy. Acridine Orange dye has been used to analyze mitochondria and lysosomal content by flow cytometry, characterize multidrug resistance, and measure changes in mitochondrial mass during apoptosis in rat thymocytes.

What are the applications of Application

Acridine Orange hemi(zinc chloride) salt is fluorescent dye that stains DNA and RNA

General Description

Acridine orange is a metachromatic fluorescent cationic dye that permeates the cell membrane and intercalates DNA and RNA. It allows for visual detection of nucleic acids on agarose and polyacrylamide gels.

Biochem/physiol Actions

Acridine orange (AO) is a fluorescent dye with two different staining characteristics. In fixed tissues, it acts as a metachromatic dye and differentially stains DNA (green) and RNA (orange). But, in living cells it acts as a pH indicator and produce brilliant orange-red in acidic condition. AO has been used to identify apoptotic cells in drosophila embryos. Acridine Orange staining method has been used to deliver more consistent data in the micronucleus test.

Properties of Basic Orange 14

Melting point: 165 °C
storage temp.  room temp
solubility  H2O: soluble1mg/mL, clear, orange to very deep orange
form  Solid
Colour Index  46005
pka pKa -3.3(H2O T=room temperature(RT) Iunspeci?ed) (Uncertain);0.2(H2O T=room temperature(RT) Iunspeci?ed) (Uncertain);10.1(H2O T=room temperature(RT) Iunspeci?ed) (Uncertain)
color  Red brown
PH 3.9 (10g/l, H2O, 20℃)
Water Solubility  soluble
Sensitive  Hygroscopic
BRN  3734978
Stability: Stable. Incompatible with strong oxidizing agents. Protect from moisture. Hygroscopic.
CAS DataBase Reference 10127-02-3(CAS DataBase Reference)

Safety information for Basic Orange 14

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H341:Germ cell mutagenicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for Basic Orange 14

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