CNX-774
- CAS NO.:1202759-32-7
- Empirical Formula: C26H22FN7O3
- Molecular Weight: 499.5
- MDL number: MFCD26405992
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:54:57
What is CNX-774?
The Uses of CNX-774
CNX-774 is an irreversible, orally active, and highly selective inhibitor of Bruton’s tyrosine kinase (BTK) and can be used for the treatment of rheumatoid arthritis (RA).
Biological Activity
cnx-774 is an orally active and selective inhibitor of btk with ic50 value of <1 nm.bruton’s tyrosine kinase (btk) is an important enzyme in the b-cell antigen receptor (bcr) signaling pathway and also plays an important role in mast cell activation and b cell maturation.cnx-774 is an orally active, irreversible and selective btk inhibitor with ic50 value of <1 nm. cnx-774 formed covalent bond with the cys481 residue within the atp binding site of btk. in cellular assays, cnx-774 inhibited btk with ic50 values of 1-10 nm [1].
References
[1]. akinleye a, chen y, mukhi n, et al. ibrutinib and novel btk inhibitors in clinical development. j hematol oncol, 2013, 6: 59.
Properties of CNX-774
Density | 1.383±0.06 g/cm3(Predicted) |
storage temp. | Store at -20° C |
solubility | Soluble in DMSO |
form | Powder |
pka | 13.22±0.70(Predicted) |
color | Light yellow to yellow |
CAS DataBase Reference | 1202759-32-7 |
Safety information for CNX-774
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for CNX-774
New Products
Tubulysin M Tubulysin I Tubulysin B Tubulysin G 3-Aminocyclobutanone hydrochloride 2H-Pyran, 4-ethynyltetrahydro- 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 4,4-DIFLUOROCYCLOHEXANAMINE 3-N-BOC-(S)-AMINO BUTYRONITRILE 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE Calcium Sodium Phosphosilicate IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell Imeglimin Hydrochloride IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (S)-4-(azidomethyl) -3-(3-fluoro-4- thiomorpholino phenyl) oxazolidin-2-one 2,3-dichloro-6- nitrobenzonitrile Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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