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HomeProduct name listASPERULOSIDE

ASPERULOSIDE

  • CAS NO.:14259-45-1
  • Empirical Formula: C18H22O11
  • Molecular Weight: 414.36
  • MDL number: MFCD31725921
  • EINECS: 238-137-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-08 20:21:46
ASPERULOSIDE Structural

What is ASPERULOSIDE?

Description

Asperuloside is an iridoid glycoside that has been found in G. tunetanum and has diverse biological activities, including anti-angiogenic, anti-inflammatory, and anti-obesity properties. It reduces microvessel formation by 67% in a chick embryo chorioallantoic membrane assay when used at a concentration of 2 μg/egg. Asperuloside (20, 40, and 80 mg/L) inhibits LPS-induced increases in TNF-α, IL-1β, and IL-6 production in RAW 264.7 macrophages in a concentration-dependent manner. It reduces lung myeloperoxidase (MPO) activity and bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and IL-6 in a mouse model of LPS-induced acute lung injury when administered at doses of 20, 40, and 80 mg/kg. Dietary administration of asperuloside decreases body weight gain, white adipose tissue (WAT) weight, and the ratio of WAT weight to body weight in a high-fat diet-induced mouse model of metabolic syndrome.

The Uses of ASPERULOSIDE

Asperuloside is an iridoid found in Paederia foetida and is an inhibitor of xanthine oxidase and is used in the treatment of various disorders including inflammatory and cardiovascular diseases.

What are the applications of Application

Asperuloside is an iridoid monoterpenoid glycoside with anti-inflammatory properties

Definition

ChEBI: A iridoid monoterpenoid glycoside isolated from Galium verum.

Properties of ASPERULOSIDE

Melting point: 131-132°
Boiling point: 704.2±60.0 °C(Predicted)
alpha  D25 -198.6° (c = 1.44 in water)
Density  1.62±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  Soluble in methanol and water
form  powder
pka 12.76±0.70(Predicted)
color  White
EPA Substance Registry System 1H-2,6-Dioxacyclopent[cd]inden-1-one, 4-[(acetyloxy)methyl]-5-(?-D-glucopyranosyloxy)-2a,4a,5,7b-tetrahydro-, (2aS,4aS,5S,7bS)- (14259-45-1)

Safety information for ASPERULOSIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P501:Dispose of contents/container to..…

Computed Descriptors for ASPERULOSIDE

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