Catalpol

Synonym(s):(1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl-β-D-glucopyranoside;Catalpinoside;De(p-hydroxybenzoyl)catalposide

CAS NO.：2415-24-9
Empirical Formula: C15H22O10
Molecular Weight: 362.33
MDL number: MFCD11111524
EINECS: 219-324-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-06 15:28:16

What is Catalpol?

Description

Catalpol is an iridoid glycoside that has been isolated from R. glutinosa and has diverse biological activities, including anti-apoptotic, pro-angiogenic, and radioprotective properties. It protects against mitochondrial pathway-dependent apoptosis in PC12 rat adrenal pheochromocytoma cells and H9c2 rat embryonic ventricular myocardial cells when used at a concentration of 10 μM. Catalpol pretreatment reduces apoptosis and improves viability in AHH-1 human lymphocyte cells exposed to ionizing radiation and reduces intestinal damage induced by radiation in mice when used at concentrations and doses ranging from of 25 to 100 μg/ml and 25 to 100 mg/kg, respectively. In a rat model of stroke, catalpol (5 mg/kg, i.p.) increases the expression of erythropoietin and VEGF and improves angiogenesis in the brain.

Chemical properties

Light brown powder

The Uses of Catalpol

Catapol is an iridoid glucoside that has been shown to alleviate neuropathic pain.

What are the applications of Application

Catapol is a compound which exhibits anti-inflammatory activity

Definition

ChEBI: Catalpol is an organic molecular entity. It has a role as a metabolite.

Properties of Catalpol

Melting point:	203-205°C
Boiling point:	675.6±55.0 °C(Predicted)
Density	1.72±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
form	Solid
pka	12.79±0.70(Predicted)
color	White to Off-White

Safety information for Catalpol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.