anhydrotetrodotoxin
- CAS NO.：13072-89-4
- Empirical Formula: C11H15N3O7
- Molecular Weight: 301.25
- MDL number: MFCD01682463
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is anhydrotetrodotoxin?
Description
4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 μM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.
storage
Store at -20°C
References
1) Rosker?et al. (2007),?The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel; Am.J.Physiol.Cell Physiol.,?293?C783. 2) Denomme?et al.?(2020),??The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6;?Neurosci. Lett.?724?134853
Properties of anhydrotetrodotoxin
| storage temp. | -20° |
| solubility | Soluble in Ethanol (up to 10 mg/ml). |
| form | A solid or film |
| color | Colorless |
| Water Solubility | Soluble to 1 mg/ml in water |
| Stability: | Stable for 2 years from date of purchase as supplied. Protect from exposure to light or moisture. Solutions are not stable. Solutions must be prepared fresh and used within 1 working day. |
Safety information for anhydrotetrodotoxin
Computed Descriptors for anhydrotetrodotoxin
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