5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide
Synonym(s):5-4(-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide
- CAS NO.:944261-79-4
- Empirical Formula: C19H16ClNO4
- Molecular Weight: 357.79
- MDL number: MFCD10574689
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-12 18:09:44
What is 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide?
Description
Nav1.8 is a tetrodotoxin-
Chemical properties
White Solid
The Uses of 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide
A selective NaV1.8 sodium channel blocker, reduces behavioral measures of chronic pain.
The Uses of 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide
A selective NaV1.8 sodium channel blocker, reduces behavioral measures of chronic pain. Analgesic.
What are the applications of Application
A-803467 is a sodium channel protein inhibitor
General Description
The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.
Biological Activity
Selective blocker of Na V 1.8 channels (IC 50 values are 8, 2450, 6740, 7340 and 7380 nM for hNa V 1.8, hNa V 1.3, hNa V 1.7, hNa V 1.5 and hNa V 1.2 channels respectively). Shows no significant activity against TRPV1, P2X 2/3 , Ca V 2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.
Biochem/physiol Actions
A-803467 blocks Nav1.8 in both half-maximal inactive and resting states with an IC50 of 8 nM and IC50 of 79 nM, respectively. A-803467 is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.
storage
+4°C
References
1) Jarvis et al. (2007), A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat; Proc. Natl. Acad. Sci. USA, 104 8520 2) McGaraughty et al. (2008), A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats; J. Pharmacol. Exp. Ther., 324 1204
Properties of 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide
Melting point: | 128-130?C |
Boiling point: | 450.6±45.0 °C(Predicted) |
Density | 1.294±0.06 g/cm3(Predicted) |
storage temp. | room temp |
solubility | DMSO: >10mg/mL |
form | powder |
pka | 11.72±0.70(Predicted) |
color | white to tan |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
Safety information for 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. |
Computed Descriptors for 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide
New Products
2,2-diethoxyethanethioamide Tubulysin G Tubulysin D Tubulysin E (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 3-N-BOC-(S)-AMINO BUTYRONITRILE 4,4-DIFLUOROPIPERIDINE 1-(1,1-Difluoroethyl)-2-fluorobenzene Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
You may like
-
A-803467 98.00% CAS 944261-79-4View Details
944261-79-4 -
A-803467 95% CAS 944261-79-4View Details
944261-79-4 -
A-803467 CAS 944261-79-4View Details
944261-79-4 -
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8