A 967079
Synonym(s):(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-penten-3-one oxime
- CAS NO.:1170613-55-4
- Empirical Formula: C12H14FNO
- Molecular Weight: 207.24
- MDL number: MFCD20488058
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-07 11:09:01
What is A 967079?
Description
A-967079 (1170613-55-4) is a TRPA1 blocker. Active in rat models.1 Cell permeable
The Uses of A 967079
(1E,3E)- 1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime is a transient receptor potential ankyrin 1 (TRPA1) antagonist and has been investigated as potential analgesic drug for the treatment of chronic pain.
The Uses of A 967079
A-967079 has been used in blocking miR-711-induced TRPA1 (transient receptor potential cation channel subfamily A member 1) channel.
What are the applications of Application
A-967079 is antagonist of Transient Receptor Potential Anykrin 1 (TRPA1)
General Description
A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury.
Biochem/physiol Actions
A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.
storage
+4°C
References
1) McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats; Mol. Pain, 6 14.
Properties of A 967079
Boiling point: | 324.4±34.0 °C(Predicted) |
Density | 1.03±0.1 g/cm3 (20 ºC 760 Torr) |
storage temp. | 2-8°C |
solubility | DMSO: ≥12mg/mL |
pka | 12.23±0.40(Predicted) |
form | powder |
color | white to tan |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months |
Safety information for A 967079
Computed Descriptors for A 967079
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