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HomeProduct name listAmodiaquin dihydrochloride dihydrate

Amodiaquin dihydrochloride dihydrate

Synonym(s):4-([7-Chloro-4-quinolinyl]amino)-2-([diethylamino]methyl)phenol;Amodiaquin dihydrochloride dihydrate

  • CAS NO.:6398-98-7
  • Empirical Formula: C20H25Cl2N3O2
  • Molecular Weight: 410.34
  • MDL number: MFCD09260307
  • EINECS: 642-210-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
Amodiaquin dihydrochloride dihydrate Structural

What is Amodiaquin dihydrochloride dihydrate?

Chemical properties

Light yellow powder

The Uses of Amodiaquin dihydrochloride dihydrate

antimalarial

The Uses of Amodiaquin dihydrochloride dihydrate

An anti-malarial quinoline derivative that acts as an histamine N-methyltransferase inhibitor

brand name

Camoquin (Parke-Davis).

Biological Activity

Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.

in vivo

In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation.

Properties of Amodiaquin dihydrochloride dihydrate

RTECS  GO7300100
storage temp.  Inert atmosphere,Room Temperature
solubility  Soluble in DMSO or methanol
form  neat
form  Solid
color  White to Yellow to Orange
λmax 342nm(MeOH)(lit.)
Merck  14,572
Stability: Hygroscopic
CAS DataBase Reference 6398-98-7(CAS DataBase Reference)

Safety information for Amodiaquin dihydrochloride dihydrate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P312:Call a POISON CENTER or doctor/physician if you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P233:Store in a well-ventilated place. Keep container tightly closed.

Computed Descriptors for Amodiaquin dihydrochloride dihydrate

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