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HomeProduct name listPyranoridine phosphate

Pyranoridine phosphate

Pyranoridine phosphate Structural

What is Pyranoridine phosphate?

The Uses of Pyranoridine phosphate

antimalarial

The Uses of Pyranoridine phosphate

Pyronaridine Phosphate is an antimalarial drug.

What are the applications of Application

Pyronaridine Tetraphosphate is an antimalarial agent

Biological Activity

pyronaridine (pnd), a synthetic quinolone derivative frequently prescribed for the treatment of malaria, is a selective and potent multidrug resistance (mdr) modulator of pgp-mediated mdr that inhibits the proliferation of a variety of tumor cells, including myeloid leukemia (k562 and k562/a02), epidermoid carcinoma (kb and kbv200), breast carcinoma (mcf-7 and mcf-7/adr), ovarian carcinoma (skov3, es-2 and pa-1), gastric carcinoma (bgc-823), colon carcinoma (lovo), hepatocellular carcinoma (smmz-7721 and qgy-7703), with the half maximal inhibition concentration ic50 values of 8.3 μm, 5.6 μm, 20.8 μm, 14.5 μm, 9.5 μm, 11 μm, 9.7 μm, 12.9 μm, 15.7 μm, 14.9 μm, 21.4 μm, 10.9 μm and 17.1 μm respectively [1].

References

[1] qi j, wang s, liu g, peng h, wang j, zhu z, yang c. pyronaridine, a novel modulator of p-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo. biochem biophys res commun. 2004 jul 9;319(4):1124-31.

Properties of Pyranoridine phosphate

Melting point: 233-236° (dec)
storage temp.  2-8°C
solubility  acetic acid: soluble5mg/mL
form  solid
color  Light yellow to yellow

Safety information for Pyranoridine phosphate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
H361:Reproductive toxicity
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Pyranoridine phosphate

InChIKey YKUQEKXHQFYULM-UHFFFAOYSA-N

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