Amino-PEG2-acid
- CAS NO.:791028-27-8
- Empirical Formula: C7H15NO4
- Molecular Weight: 177.2
- MDL number: MFCD20926377
- Update Date: 2024-07-02 08:55:13
What is Amino-PEG2-acid?
Description
Amino-PEG2-acid is a PEG reagent containing an amino group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Amino-PEG2-C2-acid is a cleavable 3-unit PEG ADClinker for the synthesis of antibody-drug conjugated Ck (ADC). It is also a PEG-based PROTAClinker that can be used for PROTAC synthesis.
in vivo
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Properties of Amino-PEG2-acid
Boiling point: | 331.5±27.0 °C(Predicted) |
Density | 1.142±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
pka | 4.27±0.10(Predicted) |
form | Solid |
color | White to off-white |
Safety information for Amino-PEG2-acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Amino-PEG2-acid
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