Heptaethylene Glycol Monomethyl Ether
Synonym(s):Methoxyheptaethylene glycol;Monomethoxy-PEG (n=7)
- CAS NO.：4437-01-8
- Empirical Formula: C15H32O8
- Molecular Weight: 340.41
- MDL number: MFCD06201006
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is Heptaethylene Glycol Monomethyl Ether ?
Description
m-PEG7-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.
The Uses of Heptaethylene Glycol Monomethyl Ether
Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization
Definition
The presence of heptaethylene glycol monomethyl ether (HGME) as a process impurity and degradation impurity in the final purified form of Benzonatate is a determining factor in establishing the safety, identity, strength, purity, and quality of the drug substance. Owing to the cutaneous toxicity of HGME in the BNZ drug substance, a suitable and selective analysis method is required for its quantitation[1].
References
[1] Lakshmi Narasimha Rao Katakam, Vishnu Murthy Marisetti, Santhosh Kumar Ettaboina. “Development and validation of LC–MS method for the determination of heptaethylene glycol monomethyl ether in benzonatate bulk drugs.” Biomedical Chromatography 35 7 (2021).
Properties of Heptaethylene Glycol Monomethyl Ether
| Boiling point: | 150 °C(Press: 0.005 Torr) |
| Density | 1.09 |
| refractive index | 1.4540-1.4580 |
| storage temp. | -20°C |
| pka | 14.36±0.10(Predicted) |
| form | clear liquid |
| color | Colorless to Light yellow to Light orange |
| InChI | InChI=1S/C15H32O8/c1-17-4-5-19-8-9-21-12-13-23-15-14-22-11-10-20-7-6-18-3-2-16/h16H,2-15H2,1H3 |
| CAS DataBase Reference | 4437-01-8(CAS DataBase Reference) |
Safety information for Heptaethylene Glycol Monomethyl Ether
Computed Descriptors for Heptaethylene Glycol Monomethyl Ether
| InChIKey | AGWKUHGLWHMYTG-UHFFFAOYSA-N |
| SMILES | C(O)COCCOCCOCCOCCOCCOCCOC |
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