3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine

CAS NO.：854601-60-8
Empirical Formula: C23H49NO11
Molecular Weight: 515.64
MDL number: MFCD27977521
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:03

What is 3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine?

Description

m-PEG11-amine is a water soluble PEG linker containing an amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media.

Biological Activity

M-PEG11-Amino is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker that can be used for PROTAC synthesis.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins

Properties of 3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine

Boiling point:	551.9±45.0 °C(Predicted)
Density	1.070±0.06 g/cm3(Predicted)
form	Solid-Liquid Mixture
pka	8.74±0.10(Predicted)
color	Colorless to off-white

Safety information for 3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.