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HomeProduct name listAmino-PEG4-acid

Amino-PEG4-acid

Synonym(s):Amino-PEG4-acid;Amino-PEG-acid;CA(PEG)4;Carboxy-PEG4-amine;NH2-PEG4-COOH

  • CAS NO.:663921-15-1
  • Empirical Formula: C11H23NO6
  • Molecular Weight: 265.3
  • MDL number: MFCD11041129
  • EINECS: 828-940-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
Amino-PEG4-acid Structural

What is Amino-PEG4-acid?

Description

Amino-PEG4-acid is a very popular PEG linker. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond, long PEG spacer increases reagent's solubility in aqueous media.

The Uses of Amino-PEG4-acid

H2N-Dpeg(4)-COOH, can be used in optical imaging of integrin αvβ3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers. Integrin αvβ3 plays great roles in tumor angiogenesis, invasion, and metastasis.

Benefits

Amino-dPEG4-acid has a primary amine and propionic acid terminating opposite ends of a 16-atoms long (18.0 ?) polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (D = 1). Moreover, it is highly hydrophilic, and it imparts hydrophilicity to conjugates that incorporate it. Amino-dPEG4-acid is useful in many different applications, including peptide synthesis, surface modification, dendrimer construction, and small molecule modification.

References

1. Improving tumor-targeting capability and pharmacokinetics of (99m)Tc-labeled cyclic RGD dimers with PEG(4) linkers. DOI:10.1021/mp800150r
2. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. DOI:10.1021/bc400050k
3. Microwave-mediated synthesis of labeled nucleotides with utility in the synthesis of DNA probes. DOI:10.1021/bc100013b
4. Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers. DOI:10.1021/bc800455p

Properties of Amino-PEG4-acid

Boiling point: 409.6±40.0 °C(Predicted)
Density  1.134±0.06 g/cm3(Predicted)
storage temp.  2-8°C
pka 4.28±0.10(Predicted)
color  White
InChI InChI=1S/C11H23NO6/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h1-10,12H2,(H,13,14)

Safety information for Amino-PEG4-acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Computed Descriptors for Amino-PEG4-acid

InChIKey DKUZHSDZSMQOGQ-UHFFFAOYSA-N
SMILES C(O)(=O)CCOCCOCCOCCOCCN

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