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HomeProduct name listAmfepramone hydrochloride

Amfepramone hydrochloride

Synonym(s):α-Diethylaminopropiophenone;α-Diethylaminopropiophenone hydrochloride

  • CAS NO.:134-80-5
  • Empirical Formula: C13H20ClNO
  • Molecular Weight: 241.76
  • MDL number: MFCD00058013
  • EINECS: 205-156-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-08 09:01:59
Amfepramone hydrochloride Structural

What is Amfepramone hydrochloride?

Chemical properties

Off-White Solid

Originator

Tenuate,Merrell National ,US,1959

The Uses of Amfepramone hydrochloride

Controlled substance (stimulant). Anorexic.

Definition

ChEBI: The hydrochloride salt of diethylpropion. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as an anoretic in the short term management of obesity.

Manufacturing Process

1,145 g of α-bromopropiophenone and 850 g of diethylamine are combined under stirring and heated on a water bath to boiling. The precipitate is filtered off under suction and washed with benzol. The filtrate is shaken up with aqueous hydrogen chloride, the aqueous solution made alkaline and etherified. The solution freed of the ether is fractionated. The boiling point (6 mm) is 140°C and the yield 800 g. The base is dissolved in acetic ester and precipitated with isopropanolic hydrogen chloride. After suction filtration and washing with ether the yield is found to be 750 g (80%)and the melting point 168°C.

Therapeutic Function

Anorexic

General Description

Because it has two large (relative to H or methyl) N-alkylsubstituents, diethylpropion hydrochloride, 1-phenyl-2-diethylaminopropan-1-one hydrochloride (Tenuate, Tepanil),has fewer sympathomimetic, cardiovascular, and CNSstimulatoryeffects than amphetamine. It is reportedly ananorexiant agent that can be used for the treatment of obesityin patients with hypertension and cardiovascular disease.According to the generalization long used for thisgroup of drugs, increasing N-alkyl size reduces central 1effects and increases β effects, even though the effects arelikely mediated principally by indirect NE release.

Properties of Amfepramone hydrochloride

Melting point: 180-1810C
Flash point: 9℃
storage temp.  Controlled Substance, -20°C Freezer
solubility  DMF: 1.25 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; Methanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
form  A crystalline solid

Safety information for Amfepramone hydrochloride

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H225:Flammable liquids
H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233:Keep container tightly closed.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

Computed Descriptors for Amfepramone hydrochloride

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