Amfepramone hydrochloride
Synonym(s):α-Diethylaminopropiophenone;α-Diethylaminopropiophenone hydrochloride
- CAS NO.:134-80-5
- Empirical Formula: C13H20ClNO
- Molecular Weight: 241.76
- MDL number: MFCD00058013
- EINECS: 205-156-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:01:59
What is Amfepramone hydrochloride?
Chemical properties
Off-White Solid
Originator
Tenuate,Merrell National ,US,1959
The Uses of Amfepramone hydrochloride
Controlled substance (stimulant). Anorexic.
Definition
ChEBI: The hydrochloride salt of diethylpropion. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as an anoretic in the short term management of obesity.
Manufacturing Process
1,145 g of α-bromopropiophenone and 850 g of diethylamine are combined under stirring and heated on a water bath to boiling. The precipitate is filtered off under suction and washed with benzol. The filtrate is shaken up with aqueous hydrogen chloride, the aqueous solution made alkaline and etherified. The solution freed of the ether is fractionated. The boiling point (6 mm) is 140°C and the yield 800 g. The base is dissolved in acetic ester and precipitated with isopropanolic hydrogen chloride. After suction filtration and washing with ether the yield is found to be 750 g (80%)and the melting point 168°C.
Therapeutic Function
Anorexic
General Description
Because it has two large (relative to H or methyl) N-alkylsubstituents, diethylpropion hydrochloride, 1-phenyl-2-diethylaminopropan-1-one hydrochloride (Tenuate, Tepanil),has fewer sympathomimetic, cardiovascular, and CNSstimulatoryeffects than amphetamine. It is reportedly ananorexiant agent that can be used for the treatment of obesityin patients with hypertension and cardiovascular disease.According to the generalization long used for thisgroup of drugs, increasing N-alkyl size reduces central 1effects and increases β effects, even though the effects arelikely mediated principally by indirect NE release.
Properties of Amfepramone hydrochloride
Melting point: | 180-1810C |
Flash point: | 9℃ |
storage temp. | Controlled Substance, -20°C Freezer |
solubility | DMF: 1.25 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; Methanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml |
form | A crystalline solid |
Safety information for Amfepramone hydrochloride
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
Computed Descriptors for Amfepramone hydrochloride
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