Phenyl salicylate
Synonym(s):Phenyl salicylate;Salol
- CAS NO.:118-55-8
- Empirical Formula: C13H10O3
- Molecular Weight: 214.22
- MDL number: MFCD00002213
- EINECS: 204-259-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-22 11:23:49
What is Phenyl salicylate?
Absorption
Rapidly absorbed. Refer to Aspirin for detailed salicylate absorption information.
Toxicity
Oral LD50 in the rat is 3000 mg/kg
Adverse effects can be divided into several categories , :
Eyes: irritation
Skin: skin irritation
Cardiovascular: rapid pulse, flushing
Central Nervous System —blurred vision, dizziness
Respiratory —shortness of breath or troubled breathing , irritation of respiratory system
Genitourinary —difficult micturition, acute urinary retention
Gastrointestinal —dry mouth, nausea/vomiting
Overdosage may be managed by inducing emesis or gastric lavage. Slow intravenous administration of physostigmine in doses of 1 to 4 mg (0.5 to 1 mg in children) repeated as needed in 1-2 h to relieve severe antimuscarinic symptoms. Administration of small doses of diazepam to control excitement and seizures may be warranted. Artificial respiration with oxygen can be used if needed for respiratory depression. Adequate hydration is important, as well as symptomatic treatment, provided as necessary .
The Uses of Phenyl salicylate
Phenyl salicylate is used as an analgesic and antipyretic. It is also used in the manufacture of polymer plastics, lacquers, waxes, polishes, adhesives, and sunscreen products(suntan oils and cremes). As light absorber to prevent discoloration of plastics. It is also a fragrance ingredient, but has limited use. in veterinary use as an external disinfectant and intestinal antiseptic agent.
Indications
Pain and fever .
Background
Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in Aspirin ). Phenyl salicylate may also be found in some antiseptic agents . It is synthesized by heating salicylic acid with phenol , .
Phenyl salicylate is used as a food additive in the USA .
This compound belongs to the class of organic compounds known as depsides and depsidones. These are polycyclic compounds that is either a polyphenolic compound composed of two or more monocyclic aromatic units linked by an ester bond (depside), or a compound containing the depsidone structure (depsidone) .
Pharmacokinetics
Phenyl salicylate has several medical uses. It can be used as an analgesic to relieve pain, as an antiseptic with antibacterial effect as well as a kind of antipyretic for the treatment of fever. It is also used for the treatment of inflammation in the lower urinary tract. It is no longer commonly applied to human medical practice but is still used in veterinary medicine .
When it is combined with methenamine, benzoic acid, phenyl salicylate, methylene blue, and hyoscyamine sulfate, it is used to relieve the discomfort, pain, frequent urge to urinate, and cramps/spasms of the urinary tract caused by a urinary tract infection or a diagnostic procedure .
Metabolism
Hydrolyzed to salicylic acid . Salicylic acid elimination kinetics are dependent on drug concentration because of the limited capacity of two major biotransformation pathways: formation of salicyluric acid and of salicyl phenolic glucuronide.
Metabolism of this drug occurs mainly in the liver, like other salicylates .
Metabolism of salicylic acid occurs through glucuronide formation (to produce salicyluric acid), and salicyl phenolic glucuronide), conjugation with glycine (to produce salicyluric acid), and oxidation to form gentisic acid. The rate of formation of salicyl phenolic glucuronide and salicyluric acid are easily saturated at low salicylic acid concentrations and their formation can be described by Michaelis-Menten kinetics .
Properties of Phenyl salicylate
Melting point: | 41-43 °C (lit.) |
Boiling point: | 172-173 °C/12 mmHg (lit.) |
Density | 1.250g/cm3 |
Flash point: | >230 °F |
storage temp. | 2-8°C |
solubility | dioxane: 0.1 g/mL, clear, colorless |
form | Fine Crystalline Powder |
color | White |
Water Solubility | Soluble in alcohol, ether, chloroform, turpentine, acetone and benzene. Sparingly soluble in chloroformbenzene. Insoluble in water. |
Safety information for Phenyl salicylate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Environment GHS09 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H411:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Phenyl salicylate
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