Alvespimycin
- CAS NO.:467214-20-6
- Empirical Formula: C32H48N4O8
- Molecular Weight: 616.75
- MDL number: MFCD08457919
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-06 15:28:16
What is Alvespimycin?
Description
Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-
Chemical properties
Solid
The Uses of Alvespimycin
17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.
The Uses of Alvespimycin
The labelled derivative of the analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). It acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.
The Uses of Alvespimycin
17-DMAG is a synthetic Geldanamycin derivative and inhibitor of Hsp90.
What are the applications of Application
17-DMAG is a synthetic Geldanamycin derivative and inhibitor of Hsp90
Definition
ChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group.
Biological Activity
Water-soluble analog of 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI 50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).
Properties of Alvespimycin
Melting point: | >270°C (dec.) |
Boiling point: | 810.5±65.0 °C(Predicted) |
Density | 1.20 |
storage temp. | Desiccate at -20°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 8.48±0.70(Predicted) |
color | Very Dark Purple |
Safety information for Alvespimycin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Alvespimycin
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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