Ethyl propiolate
Synonym(s):Ethyl acetylenecarboxylate
- CAS NO.:623-47-2
- Empirical Formula: C5H6O2
- Molecular Weight: 98.1
- MDL number: MFCD00009184
- EINECS: 210-795-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-08 13:48:25
What is Ethyl propiolate?
Chemical properties
Ethyl propiolate is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.
The Uses of Ethyl propiolate
Ethyl propiolate is used as a precursor in the preparation of substituted anthraquinones and pyrazolo[1,5-a]pyridine, which exhibits anti-inflammatory activity. Further, it is employed in the synthesis of benzene-1,2,3,5-tetracarboxylates promoted by triphenylphosphine. Its halogenated derivatives are used as a substrate for direct, asymmetric alkynylation of cyclic beta-ketoesters using chiral phase-transfer catalysts.
The Uses of Ethyl propiolate
Halogenated derivatives were used as substrates for direct, asymmetric alkynylation of cyclic ?-ketoesters using chiral phase-transfer catalysts. Also employed in a one-pot , four-component synthesis of benzene-1,2,3,5-tetracarboxylates promoted by Ph3P.
The Uses of Ethyl propiolate
In organic synthesis; peptide coupling reagent.
Definition
ChEBI: Ethyl propiolate is the ethyl ester of prop-2-ynoic acid. It is a ynoate ester, a terminal acetylenic compound and an ethyl ester.
Hazard
Flammable; lachrymator.
Properties of Ethyl propiolate
Melting point: | 9°C |
Boiling point: | 120 °C (lit.) |
Density | 0.968 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | 74 °F |
storage temp. | 2-8°C |
solubility | Miscible with alcohol. |
form | Liquid |
Specific Gravity | 0.968 |
color | Clear colorless to pale yellow |
Water Solubility | miscible |
Merck | 14,3846 |
BRN | 878250 |
Dielectric constant | 7.0 |
CAS DataBase Reference | 623-47-2(CAS DataBase Reference) |
NIST Chemistry Reference | Ethyl propiolate(623-47-2) |
Safety information for Ethyl propiolate
Signal word | Warning |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Ethyl propiolate
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New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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